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- W2990736450 endingPage "73" @default.
- W2990736450 startingPage "64" @default.
- W2990736450 abstract "Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive, and affective symptoms. Over the past 2 decades, researchers have made significant progress toward understanding the impact of mesolimbic dopamine circuitry in acute and chronic pain. These efforts have provided insights into the circuits and intracellular pathways in the brain reward center that are implicated in sensory and affective manifestations of chronic pain. Studies have also identified novel therapeutic targets as well as factors that affect treatment responsiveness. Dysregulation of dopamine function in the brain reward center may further promote comorbid mood disorders and vulnerability to addiction. This review discusses recent clinical and preclinical findings on the neuroanatomical and neurochemical adaptations triggered by prolonged pain states in the brain reward pathway. Furthermore, this discussion highlights evidence of mechanisms underlying comorbidities among pain, depression, and addiction." @default.
- W2990736450 created "2019-12-05" @default.
- W2990736450 creator A5052608926 @default.
- W2990736450 creator A5057473127 @default.
- W2990736450 creator A5090962514 @default.
- W2990736450 date "2020-01-01" @default.
- W2990736450 modified "2023-10-17" @default.
- W2990736450 title "The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities" @default.
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