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• W2990766174 abstract "To explore the value of magnetic resonance diffusion-weighted imaging (MR-DWI) for evaluating inflammatory activity of perianal Crohn's fistula. Methods: A total of 55 patients, who were diagnosed as perianal Crohn's fistula by surgery and/or endoscopy, were assessed retrospectively. All patients, underwent pelvic magnetic resonance imaging (MRI) before and 32 weeks after the treatment, were divided into 2 groups according to their response to treatment: an effective group (34 cases) and an ineffective group (21 cases). The MRI images of patients in the 2 groups were analyzed. The changes of apparent diffusion coefficient (ADC) values before and after treatment in the 2 groups were measured and compared by a paired t-test. An MRI-based score of perianal Crohn's disease severity was calculated as a reference standard, and the correlation between the ADC value and the MRI-based score was analyzed by using a Pearson correlation coefficient method. Results: In the effective group, the ADC values after therapy were significantly greater than those before therapy (P<0.05), but in the ineffective group, there was no significant difference in the ADC value between after and before therapy (P>0.05). There was a strong negative correlation between the ADC values (after and before therapy) and the MRI-based scores in all the patients [in the effective group alone (r=-0.672, P<0.01) or in the effective group + the ineffective group (r=-0.638, P<0.01)]. Conclusion: Changes in the ADC values of perianal fistula are related to the fistula activity. MR-DWI and ADC value can accurately evaluate the inflammatory activity of perianal Crohn's fistula.目的：探讨磁共振弥散加权成像(magnetic resonance diffusion-weighted imaging，MR-DWI)在评估Crohn’s肛周瘘管炎症活动度中的价值。方法：回顾性分析55例经手术和/或肠镜证实的Crohn’s病伴发肛瘘患者的临床资料，所有患者在治疗前及治疗32周后分别行MRI检查。根据治疗结果将患者分为有效组(34例)和无效组(21例)，分析两组患者治疗前后的MRI图像，测量表观弥散系数(apparent diffusion coefficient，ADC)，采用配对t检验分析两组治疗前后ADC值的变化；同时以MRI评分作为参照，分析两组患者ADC值与MRI评分之间的相关性。结果：有效组治疗后ADC值高于治疗前(P<0.05)，无效组治疗前后ADC值比较差异无明显统计学意义(P>0.05)。有效组治疗前后ADC值与MRI评分呈强负相关(r=–0.672， P<0.01)，有效组+无效组治疗前后ADC值与MRI评分亦呈强负相关(r=–0.638，P<0.01)。结论：肛周瘘管ADC值变化与病灶炎症活动度相关，MR-DWI及ADC值测量可以较准确地判断Crohn’s肛瘘的炎症活动度。." @default.
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• W2990766174 date "2019-02-28" @default.
• W2990766174 modified "2023-09-25" @default.
• W2990766174 title "[Value of magnetic resonance diffusion-weighted imaging for evaluating the inflammatory activity of perianal Crohn's fistula]." @default.
• W2990766174 doi "https://doi.org/10.11817/j.issn.1672-7347.2019.02.009" @default.
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