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• W2990772455 endingPage "113512" @default.
• W2990772455 startingPage "113512" @default.
• W2990772455 abstract "Osteoclasts are large multinucleated bone-resorbing cells derived from monocyte/macrophage lineage. Macrophage-colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) drive the multi-stage osteoclastogenesis. Transglutaminases (TGs) are Ca2+- and thiol-dependent acyl transferases and protein crosslinking enzymes. TG enzyme family contains eight catalytically active enzymes TG1-7 and Factor XIII-A (FXIII-A). Recent studies have shown that TG1, TG2, and FXIII-A are present in osteoclasts and that TG2 and FXIII-A regulate osteoclastogenesis. In this study, we examined gene and protein expression and specific activities of TG1, TG2, and FXIII-A during osteoclastogenesis using Hitomi peptides in a day-by-day manner. We report that TG activities are highest in the differentiation and early fusion phases and then decrease dramatically. TG activities were upregulated by M-CSF and downregulated by addition of RANKL. FXIII-A was dramatically downregulated by RANKL, suggesting its involvement in M-CSF-mediated precursor commitment phase. TG1 and TG2 proteins were present throughout osteoclastogenesis, suggesting that they may have functions in both differentiation and fusion. In summary, the three TGs likely exert distinct functions at different stages of osteoclastogenesis. Our work also demonstrates that the Hitomi peptides are highly specific tools for detection of distinct TGs in a system where multiple TGs are present." @default.
• W2990772455 created "2019-12-05" @default.
• W2990772455 creator A5056236772 @default.
• W2990772455 creator A5085202255 @default.
• W2990772455 date "2020-02-01" @default.
• W2990772455 modified "2023-10-17" @default.
• W2990772455 title "Assessment of expression and specific activities of transglutaminases TG1, TG2, and FXIII-A during osteoclastogenesis" @default.
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• W2990772455 doi "https://doi.org/10.1016/j.ab.2019.113512" @default.
• W2990772455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31786225" @default.
• W2990772455 hasPublicationYear "2020" @default.
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