FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990803441> ?p ?o ?g. }

• W2990803441 endingPage "132" @default.
• W2990803441 startingPage "121" @default.
• W2990803441 abstract "Societal Impact Statement Therapeutic protein production in plants is an area of great potential for increasing and improving the production of proteins for the treatment or prevention of disease in humans and other animals. There are a number of key benefits of this technique for scientists and society, as well as regulatory challenges that need to be overcome by policymakers. Increased public understanding of the costs and benefits of therapeutic protein production in plants will be instrumental in increasing the acceptance, and thus the medical and veterinary impact, of this approach. Summary Therapeutic recombinant proteins are a powerful tool for combating many diseases which have previously been hard to treat. The most utilized expression systems are Chinese Hamster Ovary cells and Escherichia coli, but all available expression systems have strengths and weaknesses regarding development time, cost, protein size, yield, growth conditions, posttranslational modifications and regulatory approval. The plant industry is well established and growing and harvesting crops is easy and affordable using current infrastructure. Growth conditions are generally simple: sunlight, water, and the addition of cheap, available fertilizers. There are multiple options for plant expression systems, including species, genetic constructs and protein targeting, each best suited to a particular type of therapeutic protein production. Transient expression systems provide a mechanism to rapidly transfect plants and produce therapeutic protein in a matter of weeks, rather than the months it can take for many competing expression systems, while proteins targeted to cereal seeds can be harvested, stored and potentially purified much more easily than in competing systems. Current challenges for plant expression systems include a lack of regulatory approval, environmental containment concerns and nonhuman glycosylation, which may limit the scope of the type of therapeutic proteins that can be manufactured in plants. The specific strengths of plant expression systems could facilitate the production of certain therapeutic proteins quickly and cheaply in the near future." @default.
• W2990803441 created "2019-12-05" @default.
• W2990803441 creator A5027762116 @default.
• W2990803441 creator A5075908413 @default.
• W2990803441 date "2019-11-28" @default.
• W2990803441 modified "2023-10-11" @default.
• W2990803441 title "Therapeutic recombinant protein production in plants: Challenges and opportunities" @default.
• W2990803441 cites W1056314668 @default.
• W2990803441 cites W1572066007 @default.
• W2990803441 cites W1577852666 @default.
• W2990803441 cites W1649656471 @default.
• W2990803441 cites W1814267858 @default.
• W2990803441 cites W1917704618 @default.
• W2990803441 cites W1966491512 @default.
• W2990803441 cites W1967681366 @default.
• W2990803441 cites W1971042251 @default.
• W2990803441 cites W1982421065 @default.
• W2990803441 cites W1986780249 @default.
• W2990803441 cites W1992050856 @default.
• W2990803441 cites W1997984454 @default.
• W2990803441 cites W2002551743 @default.
• W2990803441 cites W2003275346 @default.
• W2990803441 cites W2005921311 @default.
• W2990803441 cites W2006816471 @default.
• W2990803441 cites W2007885388 @default.
• W2990803441 cites W2009087758 @default.
• W2990803441 cites W2010818113 @default.
• W2990803441 cites W2015642880 @default.
• W2990803441 cites W2018587074 @default.
• W2990803441 cites W2018604605 @default.
• W2990803441 cites W2026777911 @default.
• W2990803441 cites W2038681957 @default.
• W2990803441 cites W2044199954 @default.
• W2990803441 cites W2044551208 @default.
• W2990803441 cites W2049322319 @default.
• W2990803441 cites W2055251699 @default.
• W2990803441 cites W2063331514 @default.
• W2990803441 cites W2065166818 @default.
• W2990803441 cites W2071909721 @default.
• W2990803441 cites W2076908796 @default.
• W2990803441 cites W2078703243 @default.
• W2990803441 cites W2081182500 @default.
• W2990803441 cites W2081190566 @default.
• W2990803441 cites W2084180910 @default.
• W2990803441 cites W2084600650 @default.
• W2990803441 cites W2088354594 @default.
• W2990803441 cites W2089011628 @default.
• W2990803441 cites W2095072719 @default.
• W2990803441 cites W2102952752 @default.
• W2990803441 cites W2103456166 @default.
• W2990803441 cites W2113881961 @default.
• W2990803441 cites W2115124797 @default.
• W2990803441 cites W2125765649 @default.
• W2990803441 cites W2129583079 @default.
• W2990803441 cites W2132219033 @default.
• W2990803441 cites W2137017491 @default.
• W2990803441 cites W2145164461 @default.
• W2990803441 cites W2149138353 @default.
• W2990803441 cites W2156801977 @default.
• W2990803441 cites W2159164339 @default.
• W2990803441 cites W2166836758 @default.
• W2990803441 cites W2167381455 @default.
• W2990803441 cites W2179908318 @default.
• W2990803441 cites W2241030903 @default.
• W2990803441 cites W2279824931 @default.
• W2990803441 cites W2475158195 @default.
• W2990803441 cites W2483255427 @default.
• W2990803441 cites W2586724023 @default.
• W2990803441 cites W2591043104 @default.
• W2990803441 cites W2612818194 @default.
• W2990803441 cites W267809647 @default.
• W2990803441 cites W2787871123 @default.
• W2990803441 cites W2804636356 @default.
• W2990803441 cites W2807572401 @default.
• W2990803441 cites W2807750849 @default.
• W2990803441 cites W2809349813 @default.
• W2990803441 cites W2886420916 @default.
• W2990803441 cites W2918677912 @default.
• W2990803441 cites W2953442312 @default.
• W2990803441 cites W3012068405 @default.
• W2990803441 cites W4230476065 @default.
• W2990803441 cites W4254699864 @default.
• W2990803441 doi "https://doi.org/10.1002/ppp3.10073" @default.
• W2990803441 hasPublicationYear "2019" @default.
• W2990803441 type Work @default.
• W2990803441 sameAs 2990803441 @default.
• W2990803441 citedByCount "97" @default.
• W2990803441 countsByYear W29908034412020 @default.
• W2990803441 countsByYear W29908034412021 @default.
• W2990803441 countsByYear W29908034412022 @default.
• W2990803441 countsByYear W29908034412023 @default.
• W2990803441 crossrefType "journal-article" @default.
• W2990803441 hasAuthorship W2990803441A5027762116 @default.
• W2990803441 hasAuthorship W2990803441A5075908413 @default.
• W2990803441 hasBestOaLocation W29908034411 @default.
• W2990803441 hasConcept C139719470 @default.
• W2990803441 hasConcept C150903083 @default.
• W2990803441 hasConcept C162324750 @default.

• next