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• W2990807725 abstract "Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. TDP-43 (TAR DNA-binding protein 43) and FUS (fused in sarcoma) are aggregation-prone RNA-binding proteins that in ALS can mislocalize to the cytoplasm of affected motor neuron cells, often forming cytoplasmic aggregates in the process. Such mislocalization and aggregation are implicated in ALS pathology, though the mechanism(s) of TDP-43 and FUS cytoplasmic toxicity remains unclear. Recently, we determined that the endocytic function aids the turnover (i.e., protein degradation) of TDP-43 and reduces TDP-43 toxicity. Here, we identified that Cdc48 and Ubx3, a Cdc48 cofactor implicated in endocytic function, regulates the turnover and toxicity of TDP-43 and FUS expressed in Saccharomyces cerevisiae. Cdc48 physically interacts and colocalizes with TDP-43, as does VCP, in ALS patient tissue. In yeast, FUS toxicity also depends strongly on endocytic function but not on autophagy under normal conditions. FUS expression also impairs endocytic function, as previously observed with TDP-43. Taken together, our data identify a role for Cdc48/VCP and endocytic function in regulating TDP-43 and FUS toxicity and turnover. Furthermore, endocytic dysfunction may be a common defect affecting the cytoplasmic clearance of ALS aggregation-prone proteins and may represent a novel therapeutic target of promise." @default.
• W2990807725 created "2019-12-05" @default.
• W2990807725 creator A5008580713 @default.
• W2990807725 creator A5013588618 @default.
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• W2990807725 creator A5065382562 @default.
• W2990807725 creator A5078404222 @default.
• W2990807725 creator A5082352652 @default.
• W2990807725 date "2020-01-30" @default.
• W2990807725 modified "2023-10-18" @default.
• W2990807725 title "Cdc48/VCP and Endocytosis Regulate TDP-43 and FUS Toxicity and Turnover" @default.
• W2990807725 cites W1536529218 @default.
• W2990807725 cites W1971323868 @default.
• W2990807725 cites W1974993490 @default.
• W2990807725 cites W1981465219 @default.
• W2990807725 cites W1983993803 @default.
• W2990807725 cites W1999030539 @default.
• W2990807725 cites W1999275385 @default.
• W2990807725 cites W1999522052 @default.
• W2990807725 cites W2003618511 @default.
• W2990807725 cites W2007647318 @default.
• W2990807725 cites W2009373631 @default.
• W2990807725 cites W2011325147 @default.
• W2990807725 cites W2014577103 @default.
• W2990807725 cites W2016332933 @default.
• W2990807725 cites W2017500053 @default.
• W2990807725 cites W2017764563 @default.
• W2990807725 cites W2018110972 @default.
• W2990807725 cites W2019215631 @default.
• W2990807725 cites W2025269346 @default.
• W2990807725 cites W2028611597 @default.
• W2990807725 cites W2030983566 @default.
• W2990807725 cites W2031769739 @default.
• W2990807725 cites W2037248246 @default.
• W2990807725 cites W2043345690 @default.
• W2990807725 cites W2046690157 @default.
• W2990807725 cites W2047350942 @default.
• W2990807725 cites W2047422395 @default.
• W2990807725 cites W2047575886 @default.
• W2990807725 cites W2050234043 @default.
• W2990807725 cites W2054650920 @default.
• W2990807725 cites W2054811674 @default.
• W2990807725 cites W2061296359 @default.
• W2990807725 cites W2065139981 @default.
• W2990807725 cites W2066107334 @default.
• W2990807725 cites W2066107559 @default.
• W2990807725 cites W2066828509 @default.
• W2990807725 cites W2073073462 @default.
• W2990807725 cites W2073910361 @default.
• W2990807725 cites W2074795212 @default.
• W2990807725 cites W2078212551 @default.
• W2990807725 cites W2079470515 @default.
• W2990807725 cites W2101858316 @default.
• W2990807725 cites W2102327538 @default.
• W2990807725 cites W2103372900 @default.
• W2990807725 cites W2104921590 @default.
• W2990807725 cites W2105028572 @default.
• W2990807725 cites W2110645858 @default.
• W2990807725 cites W2112032807 @default.
• W2990807725 cites W2112523914 @default.
• W2990807725 cites W2118213546 @default.
• W2990807725 cites W2119237787 @default.
• W2990807725 cites W2121948672 @default.
• W2990807725 cites W2126446637 @default.
• W2990807725 cites W2126569879 @default.
• W2990807725 cites W2126753299 @default.
• W2990807725 cites W2127342428 @default.
• W2990807725 cites W2131725903 @default.
• W2990807725 cites W2137721638 @default.
• W2990807725 cites W2138083025 @default.
• W2990807725 cites W2139364069 @default.
• W2990807725 cites W2139772062 @default.
• W2990807725 cites W2141523554 @default.
• W2990807725 cites W2147268537 @default.
• W2990807725 cites W2149667979 @default.
• W2990807725 cites W2158073956 @default.
• W2990807725 cites W2159354359 @default.
• W2990807725 cites W2167279371 @default.
• W2990807725 cites W2209057621 @default.
• W2990807725 cites W2214238714 @default.
• W2990807725 cites W2219462594 @default.
• W2990807725 cites W2227207443 @default.
• W2990807725 cites W2293268779 @default.
• W2990807725 cites W2296358664 @default.
• W2990807725 cites W2311204218 @default.
• W2990807725 cites W2512829170 @default.
• W2990807725 cites W2604429195 @default.
• W2990807725 cites W2606848380 @default.
• W2990807725 cites W2775661933 @default.
• W2990807725 cites W2787234767 @default.
• W2990807725 cites W2793059892 @default.
• W2990807725 cites W2808769602 @default.
• W2990807725 cites W2899020985 @default.
• W2990807725 cites W2921912860 @default.
• W2990807725 doi "https://doi.org/10.1128/mcb.00256-19" @default.
• W2990807725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6996276" @default.
• W2990807725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31767634" @default.
• W2990807725 hasPublicationYear "2020" @default.
• W2990807725 type Work @default.

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