Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990813905> ?p ?o ?g. }
- W2990813905 abstract "Abstract Gene copy number (CN) variation is known to be important in nearly every species where it has been examined. Alterations in gene CN may provide a fast way of acquiring diversity, allowing rapid adaptation under strong selective pressures, and may also be a key component of standing genetic variation within species. Cannabis sativa plants produce a distinguishing set of secondary metabolites, the cannabinoids, many of which have medicinal utility. Two major cannabinoids—THCA (delta-9-tetrahydrocannabinolic acid) and CBDA (cannabidiolic acid)—are products of a three-step biochemical pathway. Using whole-genome shotgun sequence data for 69 Cannabis cultivars from diverse lineages within the species, we found that genes encoding the synthases in this pathway vary in CN. Transcriptome sequence data show that the cannabinoid paralogs are differentially expressed among lineages within the species. We also found that CN partially explains variation in cannabinoid content levels among Cannabis plants. Our results demonstrate that biosynthetic genes found at multiple points in the pathway could be useful for breeding purposes, and suggest that natural and artificial selection have shaped CN variation. Truncations in specific paralogs are associated with lack of production of particular cannabinoids, showing how phytochemical diversity can evolve through a complex combination of processes." @default.
- W2990813905 created "2019-12-05" @default.
- W2990813905 creator A5012645270 @default.
- W2990813905 creator A5016917714 @default.
- W2990813905 creator A5023864850 @default.
- W2990813905 creator A5032507179 @default.
- W2990813905 creator A5059278980 @default.
- W2990813905 creator A5063585444 @default.
- W2990813905 creator A5067352610 @default.
- W2990813905 creator A5074593908 @default.
- W2990813905 date "2019-11-01" @default.
- W2990813905 modified "2023-10-10" @default.
- W2990813905 title "Gene copy number is associated with phytochemistry in Cannabis sativa" @default.
- W2990813905 cites W1447217750 @default.
- W2990813905 cites W1684343866 @default.
- W2990813905 cites W1967213093 @default.
- W2990813905 cites W1991927131 @default.
- W2990813905 cites W1993158258 @default.
- W2990813905 cites W2005268861 @default.
- W2990813905 cites W2006701767 @default.
- W2990813905 cites W2014606320 @default.
- W2990813905 cites W2014994755 @default.
- W2990813905 cites W2027249361 @default.
- W2990813905 cites W2027996314 @default.
- W2990813905 cites W2028458837 @default.
- W2990813905 cites W2029814483 @default.
- W2990813905 cites W2031972371 @default.
- W2990813905 cites W2041723515 @default.
- W2990813905 cites W2046352726 @default.
- W2990813905 cites W2048534686 @default.
- W2990813905 cites W2055043387 @default.
- W2990813905 cites W2062622554 @default.
- W2990813905 cites W2062678812 @default.
- W2990813905 cites W2082340690 @default.
- W2990813905 cites W2094301999 @default.
- W2990813905 cites W2097065948 @default.
- W2990813905 cites W2100305481 @default.
- W2990813905 cites W2103441770 @default.
- W2990813905 cites W2108234281 @default.
- W2990813905 cites W2110485308 @default.
- W2990813905 cites W2114062911 @default.
- W2990813905 cites W2128053994 @default.
- W2990813905 cites W2132341951 @default.
- W2990813905 cites W2135995119 @default.
- W2990813905 cites W2136826170 @default.
- W2990813905 cites W2139614828 @default.
- W2990813905 cites W2140616116 @default.
- W2990813905 cites W2141458291 @default.
- W2990813905 cites W2142819802 @default.
- W2990813905 cites W2146134654 @default.
- W2990813905 cites W2148161442 @default.
- W2990813905 cites W2148841660 @default.
- W2990813905 cites W2151144604 @default.
- W2990813905 cites W2153169507 @default.
- W2990813905 cites W2159319600 @default.
- W2990813905 cites W2169065738 @default.
- W2990813905 cites W2169449092 @default.
- W2990813905 cites W2170551349 @default.
- W2990813905 cites W2195724570 @default.
- W2990813905 cites W2235088446 @default.
- W2990813905 cites W2253496291 @default.
- W2990813905 cites W2281763285 @default.
- W2990813905 cites W2311203695 @default.
- W2990813905 cites W2409329050 @default.
- W2990813905 cites W243125011 @default.
- W2990813905 cites W2554018877 @default.
- W2990813905 cites W2556467105 @default.
- W2990813905 cites W2591976991 @default.
- W2990813905 cites W2612079819 @default.
- W2990813905 cites W2806251336 @default.
- W2990813905 cites W2888612926 @default.
- W2990813905 cites W2899284078 @default.
- W2990813905 cites W2899609811 @default.
- W2990813905 cites W2924548309 @default.
- W2990813905 cites W2950965550 @default.
- W2990813905 cites W2951522488 @default.
- W2990813905 cites W2976034505 @default.
- W2990813905 cites W309394194 @default.
- W2990813905 cites W4233859959 @default.
- W2990813905 cites W4248926103 @default.
- W2990813905 doi "https://doi.org/10.1093/aobpla/plz074" @default.
- W2990813905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6986684" @default.
- W2990813905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32010439" @default.
- W2990813905 hasPublicationYear "2019" @default.
- W2990813905 type Work @default.
- W2990813905 sameAs 2990813905 @default.
- W2990813905 citedByCount "35" @default.
- W2990813905 countsByYear W29908139052020 @default.
- W2990813905 countsByYear W29908139052021 @default.
- W2990813905 countsByYear W29908139052022 @default.
- W2990813905 countsByYear W29908139052023 @default.
- W2990813905 crossrefType "journal-article" @default.
- W2990813905 hasAuthorship W2990813905A5012645270 @default.
- W2990813905 hasAuthorship W2990813905A5016917714 @default.
- W2990813905 hasAuthorship W2990813905A5023864850 @default.
- W2990813905 hasAuthorship W2990813905A5032507179 @default.
- W2990813905 hasAuthorship W2990813905A5059278980 @default.
- W2990813905 hasAuthorship W2990813905A5063585444 @default.
- W2990813905 hasAuthorship W2990813905A5067352610 @default.
- W2990813905 hasAuthorship W2990813905A5074593908 @default.