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- W2990837477 abstract "Background: Majority of asthma patients in Thailand suffer from severe uncontrolled disease. National data of severe asthma are lack. The pilot study was performed as a part of Severe Asthma Registry of Thailand (SARP-T). Material and Method: Retrospective cohort of moderate-to-severe asthma patients (>18 years) treated between 2017 and 2018 was performed. Severe asthma was defined by ERS/ATS. Asthma medications, comorbidities, ACT, exacerbation history, spirometry and PEFR were reviewed. Chest CT, FENO, blood eosinophils, and serum IgE were examined. Results: Total 60 moderate-to-severe asthma patients were enrolled, 33 (55%) patients were classified severe asthma. Medium to high dose ICS was noted in 84.9%. Chronic rhinosinusitis and nasal polyps were higher in severe group (33.35 vs 18.5%, p=0.248 and 24.2% vs 7.4%, p=0.162, respectively). Osteoporosis was higher in severe asthma (24.2% vs 3.7%, p=0.033). Atopy was noted in two-third of both groups (p=0.755). ACT, exacerbations and clinic PEFR were similar. However, more severe airflow obstruction (post-BD FEV1/FVC) was noted in severe compared to moderate asthma (73.42 ± 12.7 vs. 79.36 ± 6.8, p= 0.032). High FENO (79.79 ± 57.14 vs. 47.21 ± 15.78 ppb, p= 0.160), high blood eosinophils (260.4 [143.6- 365] vs. 242.1 [81.5- 377.1] cells/µL p =0.68) and high IgE (470 [207-752] vs.138 [46-681.5] IU/ml p =0.159) was noted in severe compared to moderate asthma. Expiratory air trapping and bronchiectasis were more common in severe asthma; 48.5% vs 18.5%, p =0.028 and 27.3% vs 3.7%, p =0.017, respectively. Conclusions: Type 2 biomarkers had limited role for differentiating severe disease in Thai asthma cohort." @default.
- W2990837477 created "2019-12-05" @default.
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- W2990837477 date "2019-09-28" @default.
- W2990837477 modified "2023-09-27" @default.
- W2990837477 title "Severe asthma registry program of Thailand (SARP-T) under multi-disciplinary care team Ramathibodi Hospital (A pilot study)" @default.
- W2990837477 doi "https://doi.org/10.1183/13993003.congress-2019.pa4250" @default.
- W2990837477 hasPublicationYear "2019" @default.
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