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- W2990838045 abstract "The incidence of obesity has increased dramatically over the past two decades with a prevalence of approximately 40% of the adult population within the United States. The current study examines the potential for transgenerational adipocyte (fat cell) epigenetic alterations. Adipocytes were isolated from the gonadal fat pad of the great-grand offspring F3 generation 1-year old rats ancestrally exposed to DDT (dichlorodiphenyltrichloroethane), atrazine, or vehicle control in order to obtain adipocytes for DNA methylation analysis. Observations indicate that there were differential DNA methylated regions (DMRs) in the adipocytes with the lean or obese phenotypes compared to control normal (non-obese or lean) populations. The comparison of epigenetic alterations indicated that there were substantial overlaps between the different treatment lineage groups for both the lean and obese phenotypes. Novel correlated genes and gene pathways associated with DNA methylation were identified, and may aid in the discovery of potential therapeutic targets for metabolic diseases such as obesity. Observations indicate that ancestral exposures during critical windows of development can induce the epigenetic transgenerational inheritance of DNA methylation changes in adipocytes that ultimately may contribute to an altered metabolic phenotype." @default.
- W2990838045 created "2019-12-05" @default.
- W2990838045 creator A5002094830 @default.
- W2990838045 creator A5026911605 @default.
- W2990838045 creator A5027659809 @default.
- W2990838045 creator A5089568790 @default.
- W2990838045 date "2019-01-02" @default.
- W2990838045 modified "2023-10-16" @default.
- W2990838045 title "Adipocyte epigenetic alterations and potential therapeutic targets in transgenerationally inherited lean and obese phenotypes following ancestral exposures" @default.
- W2990838045 cites W1622344395 @default.
- W2990838045 cites W1897908168 @default.
- W2990838045 cites W1929970298 @default.
- W2990838045 cites W1965917470 @default.
- W2990838045 cites W1971708895 @default.
- W2990838045 cites W1972014892 @default.
- W2990838045 cites W1979020319 @default.
- W2990838045 cites W1986380124 @default.
- W2990838045 cites W1988926458 @default.
- W2990838045 cites W1990888945 @default.
- W2990838045 cites W1998007417 @default.
- W2990838045 cites W1999414155 @default.
- W2990838045 cites W2015777649 @default.
- W2990838045 cites W2018115529 @default.
- W2990838045 cites W2032727505 @default.
- W2990838045 cites W2034809501 @default.
- W2990838045 cites W2043404158 @default.
- W2990838045 cites W2045949302 @default.
- W2990838045 cites W2048130534 @default.
- W2990838045 cites W2051051060 @default.
- W2990838045 cites W2051830885 @default.
- W2990838045 cites W2053289423 @default.
- W2990838045 cites W2057443869 @default.
- W2990838045 cites W2060892630 @default.
- W2990838045 cites W2061391446 @default.
- W2990838045 cites W2065973763 @default.
- W2990838045 cites W2073058965 @default.
- W2990838045 cites W2075561917 @default.
- W2990838045 cites W2080651036 @default.
- W2990838045 cites W2081946059 @default.
- W2990838045 cites W2081985482 @default.
- W2990838045 cites W2083741783 @default.
- W2990838045 cites W2085039863 @default.
- W2990838045 cites W2086339732 @default.
- W2990838045 cites W2089825179 @default.
- W2990838045 cites W2092488650 @default.
- W2990838045 cites W2092603991 @default.
- W2990838045 cites W2097327668 @default.
- W2990838045 cites W2098690816 @default.
- W2990838045 cites W2104979480 @default.
- W2990838045 cites W2107958456 @default.
- W2990838045 cites W2112305736 @default.
- W2990838045 cites W2114104545 @default.
- W2990838045 cites W2115725229 @default.
- W2990838045 cites W2124857894 @default.
- W2990838045 cites W2127738908 @default.
- W2990838045 cites W2127974745 @default.
- W2990838045 cites W2128742947 @default.
- W2990838045 cites W2131271579 @default.
- W2990838045 cites W2131848047 @default.
- W2990838045 cites W2136138120 @default.
- W2990838045 cites W2141189887 @default.
- W2990838045 cites W2143085832 @default.
- W2990838045 cites W2143104968 @default.
- W2990838045 cites W2143230895 @default.
- W2990838045 cites W2143543251 @default.
- W2990838045 cites W2144383336 @default.
- W2990838045 cites W2146536602 @default.
- W2990838045 cites W2150318958 @default.
- W2990838045 cites W2152497434 @default.
- W2990838045 cites W2155416684 @default.
- W2990838045 cites W2158217645 @default.
- W2990838045 cites W2159482845 @default.
- W2990838045 cites W2160078193 @default.
- W2990838045 cites W2161113342 @default.
- W2990838045 cites W2162941660 @default.
- W2990838045 cites W2165329755 @default.
- W2990838045 cites W2165896427 @default.
- W2990838045 cites W2166444077 @default.
- W2990838045 cites W2170487632 @default.
- W2990838045 cites W2170551349 @default.
- W2990838045 cites W2219578023 @default.
- W2990838045 cites W2295184530 @default.
- W2990838045 cites W2336311611 @default.
- W2990838045 cites W2475923849 @default.
- W2990838045 cites W250680551 @default.
- W2990838045 cites W2526525002 @default.
- W2990838045 cites W2535762306 @default.
- W2990838045 cites W2538882155 @default.
- W2990838045 cites W2550114267 @default.
- W2990838045 cites W2612437622 @default.
- W2990838045 cites W2615637571 @default.
- W2990838045 cites W2615990196 @default.
- W2990838045 cites W2738821725 @default.
- W2990838045 cites W2740011704 @default.
- W2990838045 cites W2754253738 @default.
- W2990838045 cites W2762001107 @default.
- W2990838045 cites W2794856460 @default.
- W2990838045 cites W2806655879 @default.