FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990851413> ?p ?o ?g. }

• W2990851413 endingPage "1857" @default.
• W2990851413 startingPage "1851" @default.
• W2990851413 abstract "Proteins are effector molecules that mediate the functions of genes1,2 and modulate comorbidities3-10, behaviors and drug treatments11. They represent an enormous potential resource for personalized, systemic and data-driven diagnosis, prevention, monitoring and treatment. However, the concept of using plasma proteins for individualized health assessment across many health conditions simultaneously has not been tested. Here, we show that plasma protein expression patterns strongly encode for multiple different health states, future disease risks and lifestyle behaviors. We developed and validated protein-phenotype models for 11 different health indicators: liver fat, kidney filtration, percentage body fat, visceral fat mass, lean body mass, cardiopulmonary fitness, physical activity, alcohol consumption, cigarette smoking, diabetes risk and primary cardiovascular event risk. The analyses were prospectively planned, documented and executed at scale on archived samples and clinical data, with a total of ~85 million protein measurements in 16,894 participants. Our proof-of-concept study demonstrates that protein expression patterns reliably encode for many different health issues, and that large-scale protein scanning12-16 coupled with machine learning is viable for the development and future simultaneous delivery of multiple measures of health. We anticipate that, with further validation and the addition of more protein-phenotype models, this approach could enable a single-source, individualized so-called liquid health check." @default.
• W2990851413 created "2019-12-05" @default.
• W2990851413 creator A5002381958 @default.
• W2990851413 creator A5014786156 @default.
• W2990851413 creator A5019601645 @default.
• W2990851413 creator A5026598177 @default.
• W2990851413 creator A5031318976 @default.
• W2990851413 creator A5035192310 @default.
• W2990851413 creator A5041877631 @default.
• W2990851413 creator A5043082194 @default.
• W2990851413 creator A5055584673 @default.
• W2990851413 creator A5055843946 @default.
• W2990851413 creator A5057904076 @default.
• W2990851413 creator A5059624049 @default.
• W2990851413 creator A5060568681 @default.
• W2990851413 creator A5061387819 @default.
• W2990851413 creator A5070980712 @default.
• W2990851413 creator A5074377269 @default.
• W2990851413 creator A5077460589 @default.
• W2990851413 creator A5078780592 @default.
• W2990851413 creator A5080577250 @default.
• W2990851413 creator A5081842404 @default.
• W2990851413 creator A5087080269 @default.
• W2990851413 date "2019-12-01" @default.
• W2990851413 modified "2023-10-16" @default.
• W2990851413 title "Plasma protein patterns as comprehensive indicators of health" @default.
• W2990851413 cites W2056704280 @default.
• W2990851413 cites W2065036402 @default.
• W2990851413 cites W2066062196 @default.
• W2990851413 cites W2066356596 @default.
• W2990851413 cites W2082037132 @default.
• W2990851413 cites W2084373725 @default.
• W2990851413 cites W2084534703 @default.
• W2990851413 cites W2088749788 @default.
• W2990851413 cites W2096534426 @default.
• W2990851413 cites W2099318912 @default.
• W2990851413 cites W2099876949 @default.
• W2990851413 cites W2112316706 @default.
• W2990851413 cites W2115709314 @default.
• W2990851413 cites W2115751958 @default.
• W2990851413 cites W2122825543 @default.
• W2990851413 cites W2155965977 @default.
• W2990851413 cites W2161883681 @default.
• W2990851413 cites W2165558008 @default.
• W2990851413 cites W2172189660 @default.
• W2990851413 cites W2236077962 @default.
• W2990851413 cites W2291318674 @default.
• W2990851413 cites W2295405100 @default.
• W2990851413 cites W2351656844 @default.
• W2990851413 cites W2462540433 @default.
• W2990851413 cites W2512827249 @default.
• W2990851413 cites W2555189237 @default.
• W2990851413 cites W2569252602 @default.
• W2990851413 cites W2592727918 @default.
• W2990851413 cites W2609957770 @default.
• W2990851413 cites W2761933427 @default.
• W2990851413 cites W2767195935 @default.
• W2990851413 cites W2771029234 @default.
• W2990851413 cites W2780162034 @default.
• W2990851413 cites W2805712258 @default.
• W2990851413 cites W2806375253 @default.
• W2990851413 cites W2860509233 @default.
• W2990851413 cites W2885870007 @default.
• W2990851413 cites W2901782973 @default.
• W2990851413 cites W3143437408 @default.
• W2990851413 doi "https://doi.org/10.1038/s41591-019-0665-2" @default.
• W2990851413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6922049" @default.
• W2990851413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31792462" @default.
• W2990851413 hasPublicationYear "2019" @default.
• W2990851413 type Work @default.
• W2990851413 sameAs 2990851413 @default.
• W2990851413 citedByCount "223" @default.
• W2990851413 countsByYear W29908514132019 @default.
• W2990851413 countsByYear W29908514132020 @default.
• W2990851413 countsByYear W29908514132021 @default.
• W2990851413 countsByYear W29908514132022 @default.
• W2990851413 countsByYear W29908514132023 @default.
• W2990851413 crossrefType "journal-article" @default.
• W2990851413 hasAuthorship W2990851413A5002381958 @default.
• W2990851413 hasAuthorship W2990851413A5014786156 @default.
• W2990851413 hasAuthorship W2990851413A5019601645 @default.
• W2990851413 hasAuthorship W2990851413A5026598177 @default.
• W2990851413 hasAuthorship W2990851413A5031318976 @default.
• W2990851413 hasAuthorship W2990851413A5035192310 @default.
• W2990851413 hasAuthorship W2990851413A5041877631 @default.
• W2990851413 hasAuthorship W2990851413A5043082194 @default.
• W2990851413 hasAuthorship W2990851413A5055584673 @default.
• W2990851413 hasAuthorship W2990851413A5055843946 @default.
• W2990851413 hasAuthorship W2990851413A5057904076 @default.
• W2990851413 hasAuthorship W2990851413A5059624049 @default.
• W2990851413 hasAuthorship W2990851413A5060568681 @default.
• W2990851413 hasAuthorship W2990851413A5061387819 @default.
• W2990851413 hasAuthorship W2990851413A5070980712 @default.
• W2990851413 hasAuthorship W2990851413A5074377269 @default.
• W2990851413 hasAuthorship W2990851413A5077460589 @default.
• W2990851413 hasAuthorship W2990851413A5078780592 @default.
• W2990851413 hasAuthorship W2990851413A5080577250 @default.
• W2990851413 hasAuthorship W2990851413A5081842404 @default.

• next