Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990857710> ?p ?o ?g. }
- W2990857710 abstract "Abstract Background Irisin, a newly discovered muscle‐derived hormone, acts in different organs and tissues, improving energy homeostasis. In this study, we assessed, for the first time, the effects of intraperitoneal irisin injections on circulating levels of leptin and ghrelin, mRNA expression of the major hypothalamic appetite regulators and brain neurotrophic factors, as well as feeding behaviour in healthy mice. Methods Twelve male 6‐week‐old C57BL/6 mice were randomized into two groups and intraperitoneally injected daily with irisin (0.5 μg/g body weight) or vehicle (phosphate‐buffered saline [PBS]) for 14 days. On the last day of observation, leptin and ghrelin levels were measured with an enzyme‐linked immunosorbent assay (ELISA). mRNA levels of genes of interest were analysed by quantitative reverse transcription polymerase chain reaction (qRT‐PCR) in brain extracts. Results Irisin administration did not change leptin or ghrelin serum concentrations. However, irisin injection increased CART, POMC, NPY, and BDNF mRNA levels, without affecting the mRNA expression of AgRP, orexin, PMCH, and UCP2. Finally, over the time frame of irisin treatment, body weight and feeding behaviour were unaltered. Conclusions These results suggest that intraperitoneal injection of irisin, although without effects on feeding behaviour and body weight, can increase the expression of anorexigenic and neurotrophic genes in mouse brain." @default.
- W2990857710 created "2019-12-05" @default.
- W2990857710 creator A5010465088 @default.
- W2990857710 creator A5021200845 @default.
- W2990857710 creator A5026368733 @default.
- W2990857710 creator A5038077594 @default.
- W2990857710 creator A5080203080 @default.
- W2990857710 creator A5083891575 @default.
- W2990857710 creator A5086215637 @default.
- W2990857710 creator A5089737683 @default.
- W2990857710 date "2019-12-19" @default.
- W2990857710 modified "2023-09-27" @default.
- W2990857710 title "Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain" @default.
- W2990857710 cites W1561443084 @default.
- W2990857710 cites W1778603900 @default.
- W2990857710 cites W1931609017 @default.
- W2990857710 cites W1988803699 @default.
- W2990857710 cites W2006889378 @default.
- W2990857710 cites W2021667366 @default.
- W2990857710 cites W2064479447 @default.
- W2990857710 cites W2085397620 @default.
- W2990857710 cites W2085804706 @default.
- W2990857710 cites W2088936574 @default.
- W2990857710 cites W2096033670 @default.
- W2990857710 cites W2109309568 @default.
- W2990857710 cites W2121921343 @default.
- W2990857710 cites W2142435309 @default.
- W2990857710 cites W2147515151 @default.
- W2990857710 cites W2153263523 @default.
- W2990857710 cites W2157118250 @default.
- W2990857710 cites W2157226283 @default.
- W2990857710 cites W2167661173 @default.
- W2990857710 cites W2171376440 @default.
- W2990857710 cites W2171944308 @default.
- W2990857710 cites W2203760533 @default.
- W2990857710 cites W2287959475 @default.
- W2990857710 cites W2327030088 @default.
- W2990857710 cites W2334240341 @default.
- W2990857710 cites W2508257164 @default.
- W2990857710 cites W2587815451 @default.
- W2990857710 cites W2590014576 @default.
- W2990857710 cites W2590517466 @default.
- W2990857710 cites W2605823623 @default.
- W2990857710 cites W2623001677 @default.
- W2990857710 cites W2730592577 @default.
- W2990857710 cites W2738087337 @default.
- W2990857710 cites W2760415661 @default.
- W2990857710 cites W2762495292 @default.
- W2990857710 cites W2790943882 @default.
- W2990857710 cites W2810723452 @default.
- W2990857710 cites W2905067650 @default.
- W2990857710 cites W2914276477 @default.
- W2990857710 cites W2919998750 @default.
- W2990857710 doi "https://doi.org/10.1002/dmrr.3238" @default.
- W2990857710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31742872" @default.
- W2990857710 hasPublicationYear "2019" @default.
- W2990857710 type Work @default.
- W2990857710 sameAs 2990857710 @default.
- W2990857710 citedByCount "20" @default.
- W2990857710 countsByYear W29908577102020 @default.
- W2990857710 countsByYear W29908577102021 @default.
- W2990857710 countsByYear W29908577102022 @default.
- W2990857710 countsByYear W29908577102023 @default.
- W2990857710 crossrefType "journal-article" @default.
- W2990857710 hasAuthorship W2990857710A5010465088 @default.
- W2990857710 hasAuthorship W2990857710A5021200845 @default.
- W2990857710 hasAuthorship W2990857710A5026368733 @default.
- W2990857710 hasAuthorship W2990857710A5038077594 @default.
- W2990857710 hasAuthorship W2990857710A5080203080 @default.
- W2990857710 hasAuthorship W2990857710A5083891575 @default.
- W2990857710 hasAuthorship W2990857710A5086215637 @default.
- W2990857710 hasAuthorship W2990857710A5089737683 @default.
- W2990857710 hasConcept C104317684 @default.
- W2990857710 hasConcept C105580179 @default.
- W2990857710 hasConcept C118303440 @default.
- W2990857710 hasConcept C126322002 @default.
- W2990857710 hasConcept C134018914 @default.
- W2990857710 hasConcept C150194340 @default.
- W2990857710 hasConcept C160539049 @default.
- W2990857710 hasConcept C170493617 @default.
- W2990857710 hasConcept C2491326 @default.
- W2990857710 hasConcept C2776119998 @default.
- W2990857710 hasConcept C2779357093 @default.
- W2990857710 hasConcept C2779680196 @default.
- W2990857710 hasConcept C2780159080 @default.
- W2990857710 hasConcept C2780613262 @default.
- W2990857710 hasConcept C511355011 @default.
- W2990857710 hasConcept C55493867 @default.
- W2990857710 hasConcept C63645605 @default.
- W2990857710 hasConcept C71315377 @default.
- W2990857710 hasConcept C71924100 @default.
- W2990857710 hasConcept C75908981 @default.
- W2990857710 hasConcept C86803240 @default.
- W2990857710 hasConcept C92020748 @default.
- W2990857710 hasConceptScore W2990857710C104317684 @default.
- W2990857710 hasConceptScore W2990857710C105580179 @default.
- W2990857710 hasConceptScore W2990857710C118303440 @default.
- W2990857710 hasConceptScore W2990857710C126322002 @default.
- W2990857710 hasConceptScore W2990857710C134018914 @default.
- W2990857710 hasConceptScore W2990857710C150194340 @default.