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- W2990885519 abstract "The ultimate goal of treatment for acute myeloid leukemia (AML) is to improve survival, and the best means of doing so is through the induction of morphologic remission, which is historically most reliably achieved with intensive chemotherapy regimens. Older patients with AML are less likely to be candidates for or to benefit from intensive chemotherapy. Patients deemed ineligible for intensive therapy may nevertheless benefit from lower-intensity therapies and from newly available targeted AML treatments. Recently approved lower-intensity treatments for AML include enasidenib, ivosidenib, glasdegib, venetoclax, midostaurin, and gilteritinib, and additional promising agents are in later stages of clinical development. Noncytotoxic agents may result in slower kinetics of therapeutic activity compared to intensive regimens, and although they are generally better tolerated than intensive chemotherapy, bone marrow responses are less frequent and may take longer to achieve. Notably, newer therapies might have been considered ineffective had they been judged solely by 2003 International Working Group response criteria for AML, which were based on experience with intensive regimens in predominantly younger patients. Lower-intensity therapies may require several treatment cycles to induce responses, and failure to achieve rapid morphologic remission may not signal the need for treatment cessation or transition to alternative therapies. Additionally, even in the absence of a conventional complete remission, lower-intensity therapies may provide meaningful clinical benefit, including improved survival and quality of life, by inducing hematologic improvement and transfusion independence. Reviewed here are the mechanisms of activity and response kinetics of lower-intensity AML therapies, as well as the clinical benefits resulting from nontraditional AML responses." @default.
- W2990885519 created "2019-12-05" @default.
- W2990885519 creator A5002489867 @default.
- W2990885519 creator A5010786159 @default.
- W2990885519 creator A5032549755 @default.
- W2990885519 creator A5066934816 @default.
- W2990885519 date "2020-02-01" @default.
- W2990885519 modified "2023-10-12" @default.
- W2990885519 title "Response Kinetics and Clinical Benefits of Nonintensive AML Therapies in the Absence of Morphologic Response" @default.
- W2990885519 cites W1513468396 @default.
- W2990885519 cites W1556454749 @default.
- W2990885519 cites W1600365609 @default.
- W2990885519 cites W1615743071 @default.
- W2990885519 cites W1773455335 @default.
- W2990885519 cites W1847894796 @default.
- W2990885519 cites W1968391269 @default.
- W2990885519 cites W1970758655 @default.
- W2990885519 cites W1976076323 @default.
- W2990885519 cites W1985620267 @default.
- W2990885519 cites W1990814650 @default.
- W2990885519 cites W1992607388 @default.
- W2990885519 cites W1994169292 @default.
- W2990885519 cites W2000303013 @default.
- W2990885519 cites W2004443250 @default.
- W2990885519 cites W2006259389 @default.
- W2990885519 cites W2015755329 @default.
- W2990885519 cites W2028415754 @default.
- W2990885519 cites W2028627376 @default.
- W2990885519 cites W2032448172 @default.
- W2990885519 cites W2047122678 @default.
- W2990885519 cites W2052822682 @default.
- W2990885519 cites W2053937610 @default.
- W2990885519 cites W2054439285 @default.
- W2990885519 cites W2060991198 @default.
- W2990885519 cites W2080452140 @default.
- W2990885519 cites W2082626018 @default.
- W2990885519 cites W2086492419 @default.
- W2990885519 cites W2087387748 @default.
- W2990885519 cites W2089517211 @default.
- W2990885519 cites W2091607700 @default.
- W2990885519 cites W2102461774 @default.
- W2990885519 cites W2106084333 @default.
- W2990885519 cites W2106833395 @default.
- W2990885519 cites W2108010756 @default.
- W2990885519 cites W2109005340 @default.
- W2990885519 cites W2111988427 @default.
- W2990885519 cites W2116858301 @default.
- W2990885519 cites W2116866755 @default.
- W2990885519 cites W2119649565 @default.
- W2990885519 cites W2123032740 @default.
- W2990885519 cites W2129510594 @default.
- W2990885519 cites W2131860315 @default.
- W2990885519 cites W2139948141 @default.
- W2990885519 cites W2157287007 @default.
- W2990885519 cites W2159507916 @default.
- W2990885519 cites W2160418332 @default.
- W2990885519 cites W2164219809 @default.
- W2990885519 cites W2170075800 @default.
- W2990885519 cites W2179575275 @default.
- W2990885519 cites W2265091238 @default.
- W2990885519 cites W2265127337 @default.
- W2990885519 cites W2285019053 @default.
- W2990885519 cites W2332364317 @default.
- W2990885519 cites W2398359775 @default.
- W2990885519 cites W2517675534 @default.
- W2990885519 cites W2531543939 @default.
- W2990885519 cites W2549790759 @default.
- W2990885519 cites W2559537906 @default.
- W2990885519 cites W2588385654 @default.
- W2990885519 cites W2620653306 @default.
- W2990885519 cites W2623089849 @default.
- W2990885519 cites W2624245118 @default.
- W2990885519 cites W2654449699 @default.
- W2990885519 cites W2736181454 @default.
- W2990885519 cites W2745668487 @default.
- W2990885519 cites W2753105914 @default.
- W2990885519 cites W2753622326 @default.
- W2990885519 cites W2756912518 @default.
- W2990885519 cites W2767798380 @default.
- W2990885519 cites W2783450169 @default.
- W2990885519 cites W2783500974 @default.
- W2990885519 cites W2793154753 @default.
- W2990885519 cites W2795076534 @default.
- W2990885519 cites W2806682325 @default.
- W2990885519 cites W2807088556 @default.
- W2990885519 cites W2884246240 @default.
- W2990885519 cites W2898284215 @default.
- W2990885519 cites W2900418013 @default.
- W2990885519 cites W2902301444 @default.
- W2990885519 cites W2905344869 @default.
- W2990885519 cites W2907177400 @default.
- W2990885519 cites W2907997089 @default.
- W2990885519 cites W2908539046 @default.
- W2990885519 cites W2972731908 @default.
- W2990885519 cites W4231346141 @default.
- W2990885519 doi "https://doi.org/10.1016/j.clml.2019.11.017" @default.
- W2990885519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31862181" @default.
- W2990885519 hasPublicationYear "2020" @default.