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• W2990969314 abstract "Systemic anticoagulation may be beneficial in pulmonary arterial hypertension, but there is no randomized clinical trial data to guide therapeutic decision making, and current guidelines do not account for patient preferences or quality of life. Decision analytic models to evaluate the potential risks and benefits of systemic anticoagulation in pulmonary arterial hypertension patients, focusing on the benefit in quality-adjusted life years, may be helpful in clarifying this uncertainty. We constructed a 31-state Markov decision analytic model to explore anticoagulation and no anticoagulation strategies. Modeled patient characteristics included gender, use of central catheter-based pulmonary arterial hypertension therapy, type of pulmonary arterial hypertension (idiopathic, idiopathic pulmonary arterial hypertension, or connective-tissue associated, connective tissue disease-pulmonary arterial hypertension), and use of oral contraceptive medication by females. Modeled events included mortality, thromboembolic complications, atrial fibrillation, stroke, and anticoagulation bleeding. Deterministic and probabilistic sensitivity analyses were performed. Anticoagulation was favored in all idiopathic pulmonary arterial hypertension cases, with a gain of 0.43-0.51 quality-adjusted life years, and detrimental in all connective tissue disease-pulmonary arterial hypertension cases, with a loss of 0.66-1.89 quality-adjusted life years. Anticoagulation would need to demonstrate a hazard ratio for pulmonary arterial hypertension mortality of 0.95 or better to be favored. In our model, idiopathic pulmonary arterial hypertension patients benefit from anticoagulation in terms of quality-adjusted life years, and connective tissue disease-pulmonary arterial hypertension patients were harmed, with a hazard ratio for pulmonary arterial hypertension mortality of 0.95 or better being required to favorably impact quality-adjusted life years. These results suggest that anticoagulation significantly improves quality adjusted life years and should be offered to all idiopathic pulmonary arterial hypertension patients. Shared decision models based on these results may help clarify therapeutic decision-making uncertainty in pulmonary arterial hypertension patients." @default.
• W2990969314 created "2019-12-05" @default.
• W2990969314 creator A5002591463 @default.
• W2990969314 creator A5011538718 @default.
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• W2990969314 date "2019-10-01" @default.
• W2990969314 modified "2023-10-14" @default.
• W2990969314 title "Anticoagulation in pulmonary arterial hypertension: a decision analysis" @default.
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• W2990969314 cites W1975167661 @default.
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• W2990969314 cites W1980187445 @default.
• W2990969314 cites W1984693219 @default.
• W2990969314 cites W1994219663 @default.
• W2990969314 cites W2000113531 @default.
• W2990969314 cites W2014863823 @default.
• W2990969314 cites W2018071189 @default.
• W2990969314 cites W2022046816 @default.
• W2990969314 cites W2046133678 @default.
• W2990969314 cites W2051288479 @default.
• W2990969314 cites W2052522225 @default.
• W2990969314 cites W2061715434 @default.
• W2990969314 cites W2066157763 @default.
• W2990969314 cites W2069492532 @default.
• W2990969314 cites W2073571473 @default.
• W2990969314 cites W2076621544 @default.
• W2990969314 cites W2078345891 @default.
• W2990969314 cites W2097973238 @default.
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• W2990969314 cites W2112757583 @default.
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• W2990969314 cites W2142503372 @default.
• W2990969314 cites W2146438051 @default.
• W2990969314 cites W2148638022 @default.
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• W2990969314 cites W2162508946 @default.
• W2990969314 cites W2162586165 @default.
• W2990969314 cites W2165762371 @default.
• W2990969314 cites W2184677300 @default.
• W2990969314 cites W2225838069 @default.
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• W2990969314 cites W2473462874 @default.
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• W2990969314 doi "https://doi.org/10.1177/2045894019895451" @default.
• W2990969314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6928543" @default.
• W2990969314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31903185" @default.
• W2990969314 hasPublicationYear "2019" @default.
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