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- W2990972099 endingPage "578" @default.
- W2990972099 startingPage "569" @default.
- W2990972099 abstract "Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis. Recent improvements to analytical methods for genomics and metabolomics allow us to investigate these channels in both mutant animals and humans. In this review, we discuss three aspects of TRP channels, which are their role in metabolism, their functional characteristics, and their role in metabolic syndrome. First, we introduce each TRP channel superfamily and their particular roles in metabolism. Second, we provide evidence for which metabolites TRP channels affect, such as lipids or glucose. Third, we discuss correlations between TRP channels and obesity, diabetes, and mucolipidosis. The cellular metabolism of TRP channels gives us possible therapeutic approaches for an effective prophylaxis of metabolic syndromes." @default.
- W2990972099 created "2019-12-05" @default.
- W2990972099 creator A5011393865 @default.
- W2990972099 creator A5049799625 @default.
- W2990972099 date "2019-08-31" @default.
- W2990972099 modified "2023-10-03" @default.
- W2990972099 title "Transient Receptor Potential Channels and Metabolism." @default.
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