FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990978502> ?p ?o ?g. }

• W2990978502 abstract "Escherichia coli still serves as a beloved workhorse for the production of many biopharmaceuticals as it fulfills essential criteria, such as having fast doubling times, exhibiting a low risk of contamination, and being easy to upscale. Most industrial processes in E. coli are carried out in fed-batch mode. However, recent trends show that the biotech industry is moving toward time-independent processing, trying to improve the space-time yield, and especially targeting constant quality attributes. In the 1950s, the term chemostat was introduced for the first time by Novick and Szilard, who followed up on the previous work performed by Monod. Chemostat processing resulted in a major hype 10 years after its official introduction. However, enthusiasm decreased as experiments suffered from genetic instabilities and physiology issues. Major improvements in strain engineering and the usage of tunable promotor systems facilitated chemostat processes. In addition, critical process parameters have been identified, and the effects they have on diverse quality attributes are understood in much more depth, thereby easing process control. By pooling the knowledge gained throughout the recent years, new applications, such as parallelization, cascade processing, and population controls, are applied nowadays. However, to control the highly heterogeneous cultivation broth to achieve stable productivity throughout long-term cultivations is still tricky. Within this review, we discuss the current state of E. coli fed-batch process understanding and its tech transfer potential within continuous processing. Furthermore, the achievements in the continuous upstream applications of E. coli and the continuous downstream processing of intracellular proteins will be discussed." @default.
• W2990978502 created "2019-12-05" @default.
• W2990978502 creator A5017007688 @default.
• W2990978502 creator A5043413230 @default.
• W2990978502 creator A5055332747 @default.
• W2990978502 creator A5080708528 @default.
• W2990978502 date "2019-11-20" @default.
• W2990978502 modified "2023-10-01" @default.
• W2990978502 title "The Rocky Road From Fed-Batch to Continuous Processing With E. coli" @default.
• W2990978502 cites W105695126 @default.
• W2990978502 cites W1516116810 @default.
• W2990978502 cites W1523829503 @default.
• W2990978502 cites W1538946731 @default.
• W2990978502 cites W162328437 @default.
• W2990978502 cites W1652819724 @default.
• W2990978502 cites W1860617187 @default.
• W2990978502 cites W1873199501 @default.
• W2990978502 cites W1897428530 @default.
• W2990978502 cites W1904982948 @default.
• W2990978502 cites W1937018166 @default.
• W2990978502 cites W1944440100 @default.
• W2990978502 cites W1966645118 @default.
• W2990978502 cites W1972977981 @default.
• W2990978502 cites W1974554376 @default.
• W2990978502 cites W1975391289 @default.
• W2990978502 cites W1975519016 @default.
• W2990978502 cites W1976021580 @default.
• W2990978502 cites W1979192743 @default.
• W2990978502 cites W1981092077 @default.
• W2990978502 cites W1981918443 @default.
• W2990978502 cites W1985161570 @default.
• W2990978502 cites W1985377869 @default.
• W2990978502 cites W1987964160 @default.
• W2990978502 cites W1988681504 @default.
• W2990978502 cites W1989801492 @default.
• W2990978502 cites W1990359286 @default.
• W2990978502 cites W1991424541 @default.
• W2990978502 cites W1992202467 @default.
• W2990978502 cites W1994787582 @default.
• W2990978502 cites W1995611933 @default.
• W2990978502 cites W2000754114 @default.
• W2990978502 cites W2005700846 @default.
• W2990978502 cites W2006947259 @default.
• W2990978502 cites W2008171450 @default.
• W2990978502 cites W2009953715 @default.
• W2990978502 cites W2010167085 @default.
• W2990978502 cites W2011517230 @default.
• W2990978502 cites W2014133014 @default.
• W2990978502 cites W2017369483 @default.
• W2990978502 cites W2021199190 @default.
• W2990978502 cites W2021397130 @default.
• W2990978502 cites W2021598569 @default.
• W2990978502 cites W2023617129 @default.
• W2990978502 cites W2024335755 @default.
• W2990978502 cites W2028012324 @default.
• W2990978502 cites W2032890906 @default.
• W2990978502 cites W2033766977 @default.
• W2990978502 cites W2040202112 @default.
• W2990978502 cites W2041733552 @default.
• W2990978502 cites W2044579317 @default.
• W2990978502 cites W2047221157 @default.
• W2990978502 cites W2048590496 @default.
• W2990978502 cites W2050405684 @default.
• W2990978502 cites W2052158605 @default.
• W2990978502 cites W2066616616 @default.
• W2990978502 cites W2067137897 @default.
• W2990978502 cites W2071702693 @default.
• W2990978502 cites W2072002842 @default.
• W2990978502 cites W2072050395 @default.
• W2990978502 cites W2072311820 @default.
• W2990978502 cites W2073010988 @default.
• W2990978502 cites W2080228586 @default.
• W2990978502 cites W2085338944 @default.
• W2990978502 cites W2086440427 @default.
• W2990978502 cites W2089924785 @default.
• W2990978502 cites W2093412135 @default.
• W2990978502 cites W2099626559 @default.
• W2990978502 cites W2100562549 @default.
• W2990978502 cites W2101591208 @default.
• W2990978502 cites W2101896194 @default.
• W2990978502 cites W2105352676 @default.
• W2990978502 cites W2113196743 @default.
• W2990978502 cites W2114641752 @default.
• W2990978502 cites W2116055160 @default.
• W2990978502 cites W2116257457 @default.
• W2990978502 cites W2120310312 @default.
• W2990978502 cites W2121309615 @default.
• W2990978502 cites W2121790971 @default.
• W2990978502 cites W2122031292 @default.
• W2990978502 cites W2125637976 @default.
• W2990978502 cites W2127224317 @default.
• W2990978502 cites W2128737863 @default.
• W2990978502 cites W2129217817 @default.
• W2990978502 cites W2136688111 @default.
• W2990978502 cites W2138820253 @default.
• W2990978502 cites W2141027030 @default.
• W2990978502 cites W2148033653 @default.
• W2990978502 cites W2151447580 @default.
• W2990978502 cites W2152413278 @default.
• W2990978502 cites W2160132765 @default.

• next