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• W2990987182 endingPage "S754" @default.
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• W2990987182 abstract "Abstract Inhibition of Janus kinases [JAKs] in Crohn’s disease [CD] patients has shown conflicting results in clinical trials. Tofacitinib, a pan-JAK inhibitor, showed efficacy in ulcerative colitis [UC] and has been approved for the treatment of patients with moderate to severe UC. In contrast, studies in CD patients were disappointing and the primary end point of clinical remission could not be met in the respective phase II induction and maintenance trials. Subsequently, the clinical development of tofacitinib was discontinued in CD. In contrast, efficacy of filgotinib, a selective JAK1 inhibitor, in CD patients was demonstrated in the randomized, double-blinded, placebo-controlled phase II FITZROY study. Upadacitinib also showed promising results in a phase II trial in moderate to severe CD. Subsequently, phase III programmes in CD have been initiated for both substances, which are still ongoing. Several newer molecules of this class of orally administrated immunosuppressants are being tested in clinical programmes. The concern of side effects of systemic JAK inhibition is addressed by either exclusively intestinal action or higher selectivity [Tyk2 inhibitors]. In general, JAK inhibitors constitute a new promising class of drugs for the treatment of CD." @default.
• W2990987182 created "2019-12-05" @default.
• W2990987182 creator A5058012401 @default.
• W2990987182 date "2019-11-29" @default.
• W2990987182 modified "2023-10-09" @default.
• W2990987182 title "Efficacy of JAK inhibitors in Crohn’s Disease" @default.
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• W2990987182 doi "https://doi.org/10.1093/ecco-jcc/jjz186" @default.
• W2990987182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7395306" @default.
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