FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2990996975> ?p ?o ?g. }

• W2990996975 endingPage "352" @default.
• W2990996975 startingPage "342" @default.
• W2990996975 abstract "Dengue virus (DENV) is the most widespread arbovirus worldwide and is responsible for major outbreaks. The host's immune response plays a crucial role in controlling this infection but might also contribute to the promotion of viral spread and immunopathology. In response to DENV infection, NK cells preferentially produce cytokines and are cytotoxic in the presence of specific antibodies. Here, we identified that DENV-2 inhibits glycogen synthase kinase 3 (GSK-3) activity to subsequently induce MHC class-1-related chain (MIC) A and MIC-B expression and IL-12 production in monocyte-derived DCs, independently of the STAT-3 pathway. The inhibition of GSK-3 by DENV-2 or small molecules induced MIC-A/B expression on monocyte-derived DCs, resulting in autologous NK cells of a specific increase in IFN-γ and TNF-α production, in the absence of direct cytotoxicity. Together, these findings identified GSK-3 as a regulator of MIC-A/B expression and suggested its role in DENV-2 infection to specifically induce cytokine production by NK cells." @default.
• W2990996975 created "2019-12-05" @default.
• W2990996975 creator A5014172411 @default.
• W2990996975 creator A5031139587 @default.
• W2990996975 creator A5043124165 @default.
• W2990996975 creator A5045007591 @default.
• W2990996975 creator A5078189423 @default.
• W2990996975 date "2019-12-01" @default.
• W2990996975 modified "2023-10-04" @default.
• W2990996975 title "Glycogen synthetase kinase 3 inhibition drives MIC‐A/B to promote cytokine production by human natural killer cells in Dengue virus type 2 infection" @default.
• W2990996975 cites W1532737852 @default.
• W2990996975 cites W1936852794 @default.
• W2990996975 cites W1964799699 @default.
• W2990996975 cites W1977946100 @default.
• W2990996975 cites W1982129725 @default.
• W2990996975 cites W1992012316 @default.
• W2990996975 cites W1992508362 @default.
• W2990996975 cites W1996820257 @default.
• W2990996975 cites W2021305380 @default.
• W2990996975 cites W2023534065 @default.
• W2990996975 cites W2045014535 @default.
• W2990996975 cites W2050209022 @default.
• W2990996975 cites W2051335877 @default.
• W2990996975 cites W2052099967 @default.
• W2990996975 cites W2062934426 @default.
• W2990996975 cites W2064558921 @default.
• W2990996975 cites W2064790665 @default.
• W2990996975 cites W2072621197 @default.
• W2990996975 cites W2074165388 @default.
• W2990996975 cites W2077601386 @default.
• W2990996975 cites W2079297432 @default.
• W2990996975 cites W2092285890 @default.
• W2990996975 cites W2104685421 @default.
• W2990996975 cites W2105181802 @default.
• W2990996975 cites W2114029170 @default.
• W2990996975 cites W2116489847 @default.
• W2990996975 cites W2124103760 @default.
• W2990996975 cites W2132557616 @default.
• W2990996975 cites W2139607151 @default.
• W2990996975 cites W2146313292 @default.
• W2990996975 cites W2146783950 @default.
• W2990996975 cites W2155501777 @default.
• W2990996975 cites W2168853355 @default.
• W2990996975 cites W2170664687 @default.
• W2990996975 cites W2181263624 @default.
• W2990996975 cites W2260392875 @default.
• W2990996975 cites W2289162196 @default.
• W2990996975 cites W2558089803 @default.
• W2990996975 cites W2569558294 @default.
• W2990996975 cites W2594617075 @default.
• W2990996975 cites W2610228741 @default.
• W2990996975 cites W2620204947 @default.
• W2990996975 cites W2740763668 @default.
• W2990996975 cites W2766307215 @default.
• W2990996975 cites W2771770459 @default.
• W2990996975 cites W2783208776 @default.
• W2990996975 cites W2793836746 @default.
• W2990996975 cites W2808775113 @default.
• W2990996975 cites W2893653180 @default.
• W2990996975 cites W2914292705 @default.
• W2990996975 cites W2915056977 @default.
• W2990996975 cites W2961698635 @default.
• W2990996975 cites W2982252373 @default.
• W2990996975 cites W4211263076 @default.
• W2990996975 doi "https://doi.org/10.1002/eji.201948284" @default.
• W2990996975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31743425" @default.
• W2990996975 hasPublicationYear "2019" @default.
• W2990996975 type Work @default.
• W2990996975 sameAs 2990996975 @default.
• W2990996975 citedByCount "6" @default.
• W2990996975 countsByYear W29909969752020 @default.
• W2990996975 countsByYear W29909969752021 @default.
• W2990996975 countsByYear W29909969752022 @default.
• W2990996975 countsByYear W29909969752023 @default.
• W2990996975 crossrefType "journal-article" @default.
• W2990996975 hasAuthorship W2990996975A5014172411 @default.
• W2990996975 hasAuthorship W2990996975A5031139587 @default.
• W2990996975 hasAuthorship W2990996975A5043124165 @default.
• W2990996975 hasAuthorship W2990996975A5045007591 @default.
• W2990996975 hasAuthorship W2990996975A5078189423 @default.
• W2990996975 hasBestOaLocation W29909969751 @default.
• W2990996975 hasConcept C154317977 @default.
• W2990996975 hasConcept C159047783 @default.
• W2990996975 hasConcept C202751555 @default.
• W2990996975 hasConcept C203014093 @default.
• W2990996975 hasConcept C2778690821 @default.
• W2990996975 hasConcept C2779635636 @default.
• W2990996975 hasConcept C2781184567 @default.
• W2990996975 hasConcept C533803919 @default.
• W2990996975 hasConcept C55493867 @default.
• W2990996975 hasConcept C86803240 @default.
• W2990996975 hasConcept C8891405 @default.
• W2990996975 hasConcept C89423630 @default.
• W2990996975 hasConceptScore W2990996975C154317977 @default.
• W2990996975 hasConceptScore W2990996975C159047783 @default.
• W2990996975 hasConceptScore W2990996975C202751555 @default.
• W2990996975 hasConceptScore W2990996975C203014093 @default.
• W2990996975 hasConceptScore W2990996975C2778690821 @default.

• next