Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991033110> ?p ?o ?g. }
- W2991033110 endingPage "e1007423" @default.
- W2991033110 startingPage "e1007423" @default.
- W2991033110 abstract "As cancer advances, cells often spread from the primary tumor to other parts of the body and form metastases. This is the main cause of cancer related mortality. Here we investigate a conceptually simple model of metastasis formation where metastatic lesions are initiated at a rate which depends on the size of the primary tumor. The evolution of each metastasis is described as an independent branching process. We assume that the primary tumor is resected at a given size and study the earliest time at which any metastasis reaches a minimal detectable size. The parameters of our model are estimated independently for breast, colorectal, headneck, lung and prostate cancers. We use these estimates to compare predictions from our model with values reported in clinical literature. For some cancer types, we find a remarkably wide range of resection sizes such that metastases are very likely to be present, but none of them are detectable. Our model predicts that only very early resections can prevent recurrence, and that small delays in the time of surgery can significantly increase the recurrence probability." @default.
- W2991033110 created "2019-12-05" @default.
- W2991033110 creator A5016013089 @default.
- W2991033110 creator A5068238985 @default.
- W2991033110 date "2019-11-21" @default.
- W2991033110 modified "2023-10-16" @default.
- W2991033110 title "Cancer recurrence times from a branching process model" @default.
- W2991033110 cites W135128833 @default.
- W2991033110 cites W1513874753 @default.
- W2991033110 cites W154497988 @default.
- W2991033110 cites W1547607371 @default.
- W2991033110 cites W1566452743 @default.
- W2991033110 cites W1963747703 @default.
- W2991033110 cites W1964154017 @default.
- W2991033110 cites W1965015213 @default.
- W2991033110 cites W1965125352 @default.
- W2991033110 cites W1972269352 @default.
- W2991033110 cites W1976364680 @default.
- W2991033110 cites W1978515980 @default.
- W2991033110 cites W1979709049 @default.
- W2991033110 cites W1979774070 @default.
- W2991033110 cites W1980670449 @default.
- W2991033110 cites W1984503538 @default.
- W2991033110 cites W1985332471 @default.
- W2991033110 cites W1987861163 @default.
- W2991033110 cites W1988414899 @default.
- W2991033110 cites W1993373616 @default.
- W2991033110 cites W1995336896 @default.
- W2991033110 cites W2001092468 @default.
- W2991033110 cites W2004764331 @default.
- W2991033110 cites W2009884071 @default.
- W2991033110 cites W2013735712 @default.
- W2991033110 cites W2017890829 @default.
- W2991033110 cites W2018106070 @default.
- W2991033110 cites W2019495672 @default.
- W2991033110 cites W2020758943 @default.
- W2991033110 cites W2022302560 @default.
- W2991033110 cites W2024483026 @default.
- W2991033110 cites W2025201105 @default.
- W2991033110 cites W2025727536 @default.
- W2991033110 cites W2029620753 @default.
- W2991033110 cites W2033224863 @default.
- W2991033110 cites W2035235278 @default.
- W2991033110 cites W2040190138 @default.
- W2991033110 cites W2043313508 @default.
- W2991033110 cites W2044311845 @default.
- W2991033110 cites W2044855876 @default.
- W2991033110 cites W2045373833 @default.
- W2991033110 cites W2050146329 @default.
- W2991033110 cites W2055448832 @default.
- W2991033110 cites W2059716831 @default.
- W2991033110 cites W2061879006 @default.
- W2991033110 cites W2062152940 @default.
- W2991033110 cites W2066330900 @default.
- W2991033110 cites W2066861312 @default.
- W2991033110 cites W2068010500 @default.
- W2991033110 cites W2070487633 @default.
- W2991033110 cites W2071521653 @default.
- W2991033110 cites W2072609916 @default.
- W2991033110 cites W2077839842 @default.
- W2991033110 cites W2079266794 @default.
- W2991033110 cites W2080232352 @default.
- W2991033110 cites W2080264320 @default.
- W2991033110 cites W2080726412 @default.
- W2991033110 cites W2084092445 @default.
- W2991033110 cites W2084705972 @default.
- W2991033110 cites W2087240354 @default.
- W2991033110 cites W2088323760 @default.
- W2991033110 cites W2090157936 @default.
- W2991033110 cites W2091046934 @default.
- W2991033110 cites W2099876620 @default.
- W2991033110 cites W2102622483 @default.
- W2991033110 cites W2109199549 @default.
- W2991033110 cites W2109248500 @default.
- W2991033110 cites W2111127589 @default.
- W2991033110 cites W2115588507 @default.
- W2991033110 cites W2118632522 @default.
- W2991033110 cites W2118850351 @default.
- W2991033110 cites W2119943104 @default.
- W2991033110 cites W2120749469 @default.
- W2991033110 cites W2123276718 @default.
- W2991033110 cites W2123431502 @default.
- W2991033110 cites W2123685758 @default.
- W2991033110 cites W2125559427 @default.
- W2991033110 cites W2126788097 @default.
- W2991033110 cites W2140634848 @default.
- W2991033110 cites W2143161736 @default.
- W2991033110 cites W2143574930 @default.
- W2991033110 cites W2145990138 @default.
- W2991033110 cites W2150550712 @default.
- W2991033110 cites W2155084457 @default.
- W2991033110 cites W2156226733 @default.
- W2991033110 cites W2158742588 @default.
- W2991033110 cites W2162290846 @default.
- W2991033110 cites W2163235555 @default.
- W2991033110 cites W2166168804 @default.
- W2991033110 cites W2166692084 @default.
- W2991033110 cites W2169895148 @default.