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• W2991061499 abstract "Background Epidemiological studies have confirmed the link between exposure to fine particulate matter (PM2.5) and risk of cardiovascular diseases (CVDs), however, the underlying mechanisms remain unclear. PM2.5 may increase the risk of CVDs through its effects on blood pressure (BP).Methods Using data from the Effects of AIR pollution on cardiopuLmonary disEaSe in urban & rural reSidents in Beijing (AIRLESS) study, we examine the acute effect of ambient PM2.5 on BP. During the period of Nov-Dec 2016 (winter) and May-Jun 2017 (summer), 250 participants aged 40-70 years living in an urban or a rural site of Beijing were enrolled. Ambient PM2.5 concentrations were measured hourly at each site during this period with stationary ambient monitors (BAM/TEOM). Twelve seated BP measurements were taken across 4 visits for each participant (2 visits per season). The association between PM2.5 and BP was examined with a linear mixed-effects model adjusted for demographic, socioeconomic status (SES) and habitual parameters, ambient temperature and relative humidity.Results The daily mean (standard deviation [SD]) ambient PM2.5 concentrations during winter and summer campaign were 85.5(78.7) and 48.7(19.2) &#956;g/m3 in the urban site and 134.0(110.9) and 31.4(14.6) &#956;g/m3 in the rural site, respectively. Preliminary analyses indicates that increased exposure to ambient PM2.5 (per interquartile range [IQR] increase: 55.9-57.6 &#956;g/m3) during the prior 1-3 days is significantly associated with elevated systolic BP ranging from 1.2 (95% Confidence Interval: 0.7-1.7) to 1.8 mmHg (1.3-2.4), after adjusting for covariates (all P&lt;0.001). Similar results were found for diastolic BP. However, the association between PM2.5 and BP was no longer statistically significant after further adjustment for ambient temperature and relative humidity.Conclusions PM2.5 may exert adverse effects on BP, but this positive association was largely explained by temperature and relative humidity." @default.
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• W2991061499 date "2018-09-24" @default.
• W2991061499 modified "2023-09-23" @default.
• W2991061499 title "Acute Effects of Ambient Fine Particulate Matter on Blood Pressure: Results from the Airless Study" @default.
• W2991061499 doi "https://doi.org/10.1289/isesisee.2018.p02.1710" @default.
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