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- W2991063163 abstract "Background: Mepolizumab reduces blood and sputum eosinophils and can reduce exacerbations in severe eosinophilic asthma (SEA). However only 50% of prednisolone-dependent SEA patients are able to reduce their maintenance prednisolone. Method: We measured sputum and blood eosinophil counts and asthma control test (ACT) in 6 SEA patients on monthly Mepolizumab injection at baseline, 3, 6 and 12month of treatment. Suboptimal treatment responsiveness is defined as sputum eosinophil counts > 3% after 4 months of treatment and at least one of the following: (1) ACT score Results: Four out of the 6 SEA patients are prednisolone-dependent (medium dose 5mg daily); the remaining 2 are on fluticasone > 500mcg daily. Good treatment response was present in 3 patients and only 1 was prednisolone-dependent (table 1). Though they were able to reduce exacerbations by 66-83%, their maintenance prednisolone dose was reduced by only 0-33%. Sputum lymphocyte differential count increased in all 6 patients despite the decrease in blood and sputum eosinophil counts (Table 1). In patients with suboptimal response, their sputum showed an increase in total IgG, IgG2, anti-eosinophil peroxidase and anti-nuclear antibody, suggesting the development of an autoimmune response in severe prednisolone-dependent patients hindering treatment response." @default.
- W2991063163 created "2019-12-05" @default.
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- W2991063163 date "2019-09-28" @default.
- W2991063163 modified "2023-09-23" @default.
- W2991063163 title "A single-center observational study assessing response to mepolizumab in severe eosinophilic asthma" @default.
- W2991063163 doi "https://doi.org/10.1183/13993003.congress-2019.pa2530" @default.
- W2991063163 hasPublicationYear "2019" @default.
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