FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991070379> ?p ?o ?g. }

• W2991070379 endingPage "10185" @default.
• W2991070379 startingPage "10177" @default.
• W2991070379 abstract "Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The high expression of osteopontin (OPN) is an important factor that aggravates drug resistance and causes a poor prognosis in this disease. Therefore, understanding the molecular mechanism of OPN is critical for the treatment and prognosis of NSCLC.We used bioinformatics analysis to verify the expression of OPN in normal lung tissues and lung cancer tissues. Then we overexpressed and knocked down OPN in cell lines to detect cell proliferation, migration, invasion, and effects on signaling pathways. Finally, malignant progression and drug resistance induced by OPN were investigated by the wound healing assay, transwell assay, clone formation assay, and Western blot analysis.We verified that OPN was upregulated in NSCLC tissues, and its overexpression induced NSCLC cell proliferation, migration, and invasion via the mitogen-activated protein kinase (MAPK) pathway. Furthermore, overexpression of OPN reduced the sensitivity of NSCLC cells to cetuximab by upregulating MAPK pathway-related proteins. These results suggested that OPN promoted malignant progression and mediated drug resistance via the MAPK signaling pathway in NSCLC cells.This study reveals the important role of OPN in NSCLC cells, making it a potential target for improving chemotherapy efficiency in patients with NSCLC." @default.
• W2991070379 created "2019-12-05" @default.
• W2991070379 creator A5042241049 @default.
• W2991070379 creator A5054950470 @default.
• W2991070379 creator A5072554625 @default.
• W2991070379 creator A5082672299 @default.
• W2991070379 creator A5085148456 @default.
• W2991070379 date "2019-11-01" @default.
• W2991070379 modified "2023-10-15" @default.
• W2991070379 title "<p>Osteopontin Mediates Cetuximab Resistance via the MAPK Pathway in NSCLC Cells</p>" @default.
• W2991070379 cites W1493048246 @default.
• W2991070379 cites W1637113035 @default.
• W2991070379 cites W1965769379 @default.
• W2991070379 cites W1967446368 @default.
• W2991070379 cites W1969942127 @default.
• W2991070379 cites W2011451070 @default.
• W2991070379 cites W2014754886 @default.
• W2991070379 cites W2027230614 @default.
• W2991070379 cites W2030432971 @default.
• W2991070379 cites W2044545697 @default.
• W2991070379 cites W2046759180 @default.
• W2991070379 cites W2046890706 @default.
• W2991070379 cites W2047004048 @default.
• W2991070379 cites W2050119770 @default.
• W2991070379 cites W2068669225 @default.
• W2991070379 cites W2070544303 @default.
• W2991070379 cites W2097413644 @default.
• W2991070379 cites W2099269691 @default.
• W2991070379 cites W2099755355 @default.
• W2991070379 cites W2103952088 @default.
• W2991070379 cites W2104479942 @default.
• W2991070379 cites W2111759875 @default.
• W2991070379 cites W2112056046 @default.
• W2991070379 cites W2112660136 @default.
• W2991070379 cites W2130461015 @default.
• W2991070379 cites W2139697170 @default.
• W2991070379 cites W2140484012 @default.
• W2991070379 cites W2143699888 @default.
• W2991070379 cites W2146994889 @default.
• W2991070379 cites W2155384808 @default.
• W2991070379 cites W2166720958 @default.
• W2991070379 cites W2168197710 @default.
• W2991070379 cites W2200765141 @default.
• W2991070379 cites W2235523093 @default.
• W2991070379 cites W2471378219 @default.
• W2991070379 cites W2570618306 @default.
• W2991070379 cites W2588094244 @default.
• W2991070379 cites W2625214598 @default.
• W2991070379 cites W2765782352 @default.
• W2991070379 cites W2800407669 @default.
• W2991070379 cites W2892173453 @default.
• W2991070379 cites W2938373751 @default.
• W2991070379 cites W2965105515 @default.
• W2991070379 cites W4207004940 @default.
• W2991070379 cites W4242648511 @default.
• W2991070379 doi "https://doi.org/10.2147/ott.s228437" @default.
• W2991070379 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6884967" @default.
• W2991070379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32063712" @default.
• W2991070379 hasPublicationYear "2019" @default.
• W2991070379 type Work @default.
• W2991070379 sameAs 2991070379 @default.
• W2991070379 citedByCount "3" @default.
• W2991070379 countsByYear W29910703792022 @default.
• W2991070379 countsByYear W29910703792023 @default.
• W2991070379 crossrefType "journal-article" @default.
• W2991070379 hasAuthorship W2991070379A5042241049 @default.
• W2991070379 hasAuthorship W2991070379A5054950470 @default.
• W2991070379 hasAuthorship W2991070379A5072554625 @default.
• W2991070379 hasAuthorship W2991070379A5082672299 @default.
• W2991070379 hasAuthorship W2991070379A5085148456 @default.
• W2991070379 hasBestOaLocation W29910703791 @default.
• W2991070379 hasConcept C104317684 @default.
• W2991070379 hasConcept C121608353 @default.
• W2991070379 hasConcept C126322002 @default.
• W2991070379 hasConcept C127561419 @default.
• W2991070379 hasConcept C143998085 @default.
• W2991070379 hasConcept C185592680 @default.
• W2991070379 hasConcept C203014093 @default.
• W2991070379 hasConcept C2776256026 @default.
• W2991070379 hasConcept C2779998722 @default.
• W2991070379 hasConcept C2780804394 @default.
• W2991070379 hasConcept C502942594 @default.
• W2991070379 hasConcept C526805850 @default.
• W2991070379 hasConcept C55493867 @default.
• W2991070379 hasConcept C57074206 @default.
• W2991070379 hasConcept C62112901 @default.
• W2991070379 hasConcept C62478195 @default.
• W2991070379 hasConcept C71924100 @default.
• W2991070379 hasConcept C86803240 @default.
• W2991070379 hasConcept C95444343 @default.
• W2991070379 hasConceptScore W2991070379C104317684 @default.
• W2991070379 hasConceptScore W2991070379C121608353 @default.
• W2991070379 hasConceptScore W2991070379C126322002 @default.
• W2991070379 hasConceptScore W2991070379C127561419 @default.
• W2991070379 hasConceptScore W2991070379C143998085 @default.
• W2991070379 hasConceptScore W2991070379C185592680 @default.
• W2991070379 hasConceptScore W2991070379C203014093 @default.
• W2991070379 hasConceptScore W2991070379C2776256026 @default.

• next