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- W2991090744 abstract "Erlotinib-loaded carboxymethyl temarind gum-g-poly(N-isopropylacrylamide)-montmorillonite based semi-IPN nanocomposites were synthesized and characterized for their in vitro performances for lung cancer therapy. The placebo matrices exhibited outstanding biodegradability and pH-dependent swelling profiles. The molar mass (M¯ c) between the crosslinks of these composites was declined with temperature. The solid state characterization confirmed the semi-IPN architecture of these scaffolds. The corresponding drug-loaded formulations displayed excellent drug-trapping capacity (DEE, 86–97 %) with acceptable zeta potential (−16 to −13 mV) and diameter (967−646 nm). These formulations conferred sustained drug elution profiles (Q8h, 77–99 %) with an initial burst release. The drug release profile of the optimized formulation (F-3) was best fitted in the first order kinetic model with Fickian diffusion driven mechanism. The mucin adsorption to F-3 followed Langmuir isotherms. The results of MTT assay, AO/EB staining and confocal analyses revealed that the ERL-loaded formulation suppressed A549 cell proliferation and induced apoptosis more effectively than pristine drug." @default.
- W2991090744 created "2019-12-05" @default.
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- W2991090744 date "2020-02-01" @default.
- W2991090744 modified "2023-10-17" @default.
- W2991090744 title "Erlotinib-loaded carboxymethyl temarind gum semi-interpenetrating nanocomposites" @default.
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- W2991090744 doi "https://doi.org/10.1016/j.carbpol.2019.115664" @default.
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