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- W2991100954 abstract "In this paper, we summarize published articles and experiences related to the attempt to improve radiotherapy outcomes and, thus, to personalize the radiation treatment according to the individual characteristics of each patient. The evolution of ideas and the study of successively published data have led us to envisage new biophysical models for the interpretation of tumor and healthy normal tissue response to radiation. In the development of the model, we have shown that when mesenchymal stem cells (MSCs) and radiotherapy are administered simultaneously in experimental radiotherapy on xenotumors implanted in a murine model, the results of the treatment show the existence of a synergic mechanism that is able to enhance the local and systemic actions of the radiation both on the treated tumor and on its possible metastasis. We are convinced that, due to the physical hallmarks that characterize the neoplastic tissues, the physical-chemical tropism of MSCs, and the widespread functions of macromolecules, proteins, and exosomes released from activated MSCs, the combination of radiotherapy plus MSCs used intratumorally has the effect of counteracting the pro-tumorigenic and pro-metastatic signals that contribute to the growth, spread, and resistance of the tumor cells. Therefore, we have concluded that MSCs are appropriate for therapeutic use in a clinical trial for rectal cancer combined with radiotherapy, which we are going to start in the near future." @default.
- W2991100954 created "2019-12-05" @default.
- W2991100954 creator A5012468298 @default.
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- W2991100954 creator A5065649135 @default.
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- W2991100954 date "2020-01-08" @default.
- W2991100954 modified "2023-10-13" @default.
- W2991100954 title "Enhancing the Bystander and Abscopal Effects to Improve Radiotherapy Outcomes" @default.
- W2991100954 cites W1103823873 @default.
- W2991100954 cites W1200454557 @default.
- W2991100954 cites W1490612320 @default.
- W2991100954 cites W1511291983 @default.
- W2991100954 cites W1531059701 @default.
- W2991100954 cites W1584316469 @default.
- W2991100954 cites W1701298882 @default.
- W2991100954 cites W1853400898 @default.
- W2991100954 cites W1895814318 @default.
- W2991100954 cites W1943338723 @default.
- W2991100954 cites W1950118853 @default.
- W2991100954 cites W1955548161 @default.
- W2991100954 cites W1964476212 @default.
- W2991100954 cites W1965730378 @default.
- W2991100954 cites W1966550708 @default.
- W2991100954 cites W1971747664 @default.
- W2991100954 cites W1976222088 @default.
- W2991100954 cites W1979837801 @default.
- W2991100954 cites W1984423771 @default.
- W2991100954 cites W1987141741 @default.
- W2991100954 cites W1987238939 @default.
- W2991100954 cites W1987398988 @default.
- W2991100954 cites W1991251712 @default.
- W2991100954 cites W2003935198 @default.
- W2991100954 cites W2004855922 @default.
- W2991100954 cites W2005488333 @default.
- W2991100954 cites W2006317510 @default.
- W2991100954 cites W2011885150 @default.
- W2991100954 cites W2014433188 @default.
- W2991100954 cites W2014808449 @default.
- W2991100954 cites W2018398216 @default.
- W2991100954 cites W2018998320 @default.
- W2991100954 cites W2021912098 @default.
- W2991100954 cites W2023808544 @default.
- W2991100954 cites W2027063581 @default.
- W2991100954 cites W2029224024 @default.
- W2991100954 cites W2029652537 @default.
- W2991100954 cites W2030075101 @default.
- W2991100954 cites W2038745583 @default.
- W2991100954 cites W2043043829 @default.
- W2991100954 cites W2052365777 @default.
- W2991100954 cites W2054749775 @default.
- W2991100954 cites W2055590754 @default.
- W2991100954 cites W2056363422 @default.
- W2991100954 cites W2058257534 @default.
- W2991100954 cites W2061039816 @default.
- W2991100954 cites W2061137918 @default.
- W2991100954 cites W2061279503 @default.
- W2991100954 cites W2061795391 @default.
- W2991100954 cites W2062007210 @default.
- W2991100954 cites W2064641323 @default.
- W2991100954 cites W2072153851 @default.
- W2991100954 cites W2074084795 @default.
- W2991100954 cites W2074171762 @default.
- W2991100954 cites W2075879891 @default.
- W2991100954 cites W2076659634 @default.
- W2991100954 cites W2077007959 @default.
- W2991100954 cites W2077368333 @default.
- W2991100954 cites W2079690907 @default.
- W2991100954 cites W2082769667 @default.
- W2991100954 cites W2082776802 @default.
- W2991100954 cites W2087671265 @default.
- W2991100954 cites W2089804431 @default.
- W2991100954 cites W2090686781 @default.
- W2991100954 cites W2097659667 @default.
- W2991100954 cites W2102660785 @default.
- W2991100954 cites W2106428582 @default.
- W2991100954 cites W2108789863 @default.
- W2991100954 cites W2110081577 @default.
- W2991100954 cites W2110565428 @default.
- W2991100954 cites W2111977682 @default.
- W2991100954 cites W2112699943 @default.
- W2991100954 cites W2117280704 @default.
- W2991100954 cites W2117692326 @default.
- W2991100954 cites W2120620347 @default.
- W2991100954 cites W2126375072 @default.
- W2991100954 cites W2128625986 @default.
- W2991100954 cites W2129299671 @default.
- W2991100954 cites W2129974873 @default.
- W2991100954 cites W2130211103 @default.
- W2991100954 cites W2131109132 @default.
- W2991100954 cites W2131369455 @default.
- W2991100954 cites W2132738790 @default.
- W2991100954 cites W2133739473 @default.
- W2991100954 cites W2135193866 @default.
- W2991100954 cites W2136829301 @default.
- W2991100954 cites W2137210293 @default.
- W2991100954 cites W2150022465 @default.