FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991107300> ?p ?o ?g. }

• W2991107300 endingPage "e0225251" @default.
• W2991107300 startingPage "e0225251" @default.
• W2991107300 abstract "Monitoring genetic diversity and drug resistance mutations (DRMs) is critical for understanding HIV epidemiology. Here, we report HIV-1 genetic diversity and DRMs in blood samples from 42 HIV-positive pregnant women naive to antiretroviral therapy (ART), in Luanda. The samples were subjected to nested-PCR, followed by sequencing of HIV-1 pol gene, targeting the protease and reverse transcriptase fragments. HIV-1 diversity was analyzed using the REGA HIV-1 subtyping tool and DRMs were identified using the Calibrated Population Resistance tool. A total of 34 sequences were obtained. The data revealed wide HIV-1 subtypes heterogeneity, with subtype C (38%, 13/34) the most frequent, followed by the subtypes F1 (18%, 6/34), A1 (9%, 3/34), G (9%, 3/34), D (6%, 2/34) and H (3%, 1/34). In addition, recombinants strains were detected, with CRF02_AG (6%, 2/34) the most frequent, followed by CRF37_cpx, F1/C, A1/G and H/G, all with 3% (1/34). A total of 6/34 (18%) of the sequences presented DRMs. The non-nucleoside reverse transcriptase inhibitors presented 15% (5/34) of resistance. Moreover, 1/34 (3%) sequence presented resistance against both non-nucleoside reverse transcriptase inhibitors and nucleoside reverse transcriptase inhibitors, simultaneously. Despite the small sample size, our results suggest the need to update currently used ART regimens. Surveillance of HIV-1 subtypes and DRMs are necessary to understand HIV epidemiology and to guide modification of ART guidelines in Angola." @default.
• W2991107300 created "2019-12-05" @default.
• W2991107300 creator A5002108755 @default.
• W2991107300 creator A5035009802 @default.
• W2991107300 creator A5040951375 @default.
• W2991107300 creator A5044017039 @default.
• W2991107300 creator A5055870287 @default.
• W2991107300 creator A5062133350 @default.
• W2991107300 creator A5065467974 @default.
• W2991107300 creator A5076108082 @default.
• W2991107300 creator A5089999269 @default.
• W2991107300 date "2019-11-26" @default.
• W2991107300 modified "2023-10-09" @default.
• W2991107300 title "Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola" @default.
• W2991107300 cites W107872265 @default.
• W2991107300 cites W1969028669 @default.
• W2991107300 cites W2013314522 @default.
• W2991107300 cites W2030966943 @default.
• W2991107300 cites W2038805079 @default.
• W2991107300 cites W2042007272 @default.
• W2991107300 cites W2045300036 @default.
• W2991107300 cites W2046828783 @default.
• W2991107300 cites W2048253923 @default.
• W2991107300 cites W2055463718 @default.
• W2991107300 cites W2067965261 @default.
• W2991107300 cites W2097706568 @default.
• W2991107300 cites W2109046728 @default.
• W2991107300 cites W2128792719 @default.
• W2991107300 cites W2134297712 @default.
• W2991107300 cites W2140227530 @default.
• W2991107300 cites W2144775551 @default.
• W2991107300 cites W2154164013 @default.
• W2991107300 cites W2159181197 @default.
• W2991107300 cites W2163400707 @default.
• W2991107300 cites W2166197134 @default.
• W2991107300 cites W2311203695 @default.
• W2991107300 cites W2400580124 @default.
• W2991107300 cites W2461950102 @default.
• W2991107300 cites W2924309353 @default.
• W2991107300 cites W2925271821 @default.
• W2991107300 doi "https://doi.org/10.1371/journal.pone.0225251" @default.
• W2991107300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6879122" @default.
• W2991107300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31770425" @default.
• W2991107300 hasPublicationYear "2019" @default.
• W2991107300 type Work @default.
• W2991107300 sameAs 2991107300 @default.
• W2991107300 citedByCount "5" @default.
• W2991107300 countsByYear W29911073002020 @default.
• W2991107300 countsByYear W29911073002021 @default.
• W2991107300 countsByYear W29911073002022 @default.
• W2991107300 crossrefType "journal-article" @default.
• W2991107300 hasAuthorship W2991107300A5002108755 @default.
• W2991107300 hasAuthorship W2991107300A5035009802 @default.
• W2991107300 hasAuthorship W2991107300A5040951375 @default.
• W2991107300 hasAuthorship W2991107300A5044017039 @default.
• W2991107300 hasAuthorship W2991107300A5055870287 @default.
• W2991107300 hasAuthorship W2991107300A5062133350 @default.
• W2991107300 hasAuthorship W2991107300A5065467974 @default.
• W2991107300 hasAuthorship W2991107300A5076108082 @default.
• W2991107300 hasAuthorship W2991107300A5089999269 @default.
• W2991107300 hasBestOaLocation W29911073001 @default.
• W2991107300 hasConcept C104317684 @default.
• W2991107300 hasConcept C114851261 @default.
• W2991107300 hasConcept C156719811 @default.
• W2991107300 hasConcept C159047783 @default.
• W2991107300 hasConcept C199360897 @default.
• W2991107300 hasConcept C2779690655 @default.
• W2991107300 hasConcept C2780727368 @default.
• W2991107300 hasConcept C2908647359 @default.
• W2991107300 hasConcept C2909970146 @default.
• W2991107300 hasConcept C3013748606 @default.
• W2991107300 hasConcept C41008148 @default.
• W2991107300 hasConcept C49105822 @default.
• W2991107300 hasConcept C54355233 @default.
• W2991107300 hasConcept C71924100 @default.
• W2991107300 hasConcept C81977670 @default.
• W2991107300 hasConcept C83852419 @default.
• W2991107300 hasConcept C86803240 @default.
• W2991107300 hasConcept C99454951 @default.
• W2991107300 hasConceptScore W2991107300C104317684 @default.
• W2991107300 hasConceptScore W2991107300C114851261 @default.
• W2991107300 hasConceptScore W2991107300C156719811 @default.
• W2991107300 hasConceptScore W2991107300C159047783 @default.
• W2991107300 hasConceptScore W2991107300C199360897 @default.
• W2991107300 hasConceptScore W2991107300C2779690655 @default.
• W2991107300 hasConceptScore W2991107300C2780727368 @default.
• W2991107300 hasConceptScore W2991107300C2908647359 @default.
• W2991107300 hasConceptScore W2991107300C2909970146 @default.
• W2991107300 hasConceptScore W2991107300C3013748606 @default.
• W2991107300 hasConceptScore W2991107300C41008148 @default.
• W2991107300 hasConceptScore W2991107300C49105822 @default.
• W2991107300 hasConceptScore W2991107300C54355233 @default.
• W2991107300 hasConceptScore W2991107300C71924100 @default.
• W2991107300 hasConceptScore W2991107300C81977670 @default.
• W2991107300 hasConceptScore W2991107300C83852419 @default.
• W2991107300 hasConceptScore W2991107300C86803240 @default.
• W2991107300 hasConceptScore W2991107300C99454951 @default.
• W2991107300 hasFunder F4320323917 @default.

• next