FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991151454> ?p ?o ?g. }

• W2991151454 abstract "Abstract Background Inflammation in the brain is mediated by the cyclooxygenase pathway, which leads to the production of prostaglandins. Prostaglandin (PG) D2, the most abundant PG in the brain, increases under pathological conditions and is spontaneously metabolized to PGJ2. PGJ2 is highly neurotoxic, with the potential to transition neuroinflammation into a chronic state and contribute to neurodegeneration as seen in many neurological diseases. Conversely, PACAP27 is a lipophilic peptide that raises intracellular cAMP and is an anti‐inflammatory agent. The aim of our study was to investigate the therapeutic potential of PACAP27 to counter the behavioral and neurotoxic effects of PGJ2 observed in aged subjects. Methods PGJ2 was injected bilaterally into the hippocampal CA1 region of 53‐week‐old and 12‐week‐old C57BL/6N male mice, once per week over 3 weeks (three total infusions) and included co‐infusions of PACAP27 within respective treatment groups. Our behavioral assessments looked at spatial learning and memory performance on the 8‐arm radial maze, followed by histological analyses of fixed hippocampal tissue using Fluoro‐Jade C and fluorescent immunohistochemistry focused on IBA‐1 microglia. Results Aged mice treated with PGJ2 exhibited spatial learning and long‐term memory deficits, as well as neurodegeneration in CA3 pyramidal neurons. Aged mice that received co‐infusions of PACAP27 exhibited remediated learning and memory performance and decreased neurodegeneration in CA3 pyramidal neurons. Moreover, microglial activation in the CA3 region was also reduced in aged mice cotreated with PACAP27. Conclusions Our data show that PGJ2 can produce a retrograde spread of damage not observed in PGJ2‐treated young mice, leading to age‐dependent neurodegeneration of hippocampal neurons producing learning and memory deficits. PACAP27 can remediate the behavioral and neurodegenerative effects that PGJ2 produces in aged subjects. Targeting specific neurotoxic prostaglandins, such as PGJ2, offers great promise as a new therapeutic strategy downstream of cyclooxygenases, to combat the neuronal deficits induced by chronic inflammation." @default.
• W2991151454 created "2019-12-05" @default.
• W2991151454 creator A5002567720 @default.
• W2991151454 creator A5007845346 @default.
• W2991151454 creator A5024300994 @default.
• W2991151454 creator A5040409459 @default.
• W2991151454 creator A5070627672 @default.
• W2991151454 creator A5089353076 @default.
• W2991151454 date "2019-11-25" @default.
• W2991151454 modified "2023-09-27" @default.
• W2991151454 title "PACAP27 mitigates an age‐dependent hippocampal vulnerability to PGJ2‐induced spatial learning deficits and neuroinflammation in mice" @default.
• W2991151454 cites W1496633211 @default.
• W2991151454 cites W1516122098 @default.
• W2991151454 cites W1528048182 @default.
• W2991151454 cites W1633358180 @default.
• W2991151454 cites W1816777554 @default.
• W2991151454 cites W187277792 @default.
• W2991151454 cites W1965728735 @default.
• W2991151454 cites W1965942744 @default.
• W2991151454 cites W1966388129 @default.
• W2991151454 cites W1966918485 @default.
• W2991151454 cites W1968152111 @default.
• W2991151454 cites W1972954562 @default.
• W2991151454 cites W1973872423 @default.
• W2991151454 cites W1975590436 @default.
• W2991151454 cites W1975765156 @default.
• W2991151454 cites W1976728837 @default.
• W2991151454 cites W1977047599 @default.
• W2991151454 cites W1980410293 @default.
• W2991151454 cites W1984891266 @default.
• W2991151454 cites W1985815419 @default.
• W2991151454 cites W1987123448 @default.
• W2991151454 cites W1989775722 @default.
• W2991151454 cites W1990374107 @default.
• W2991151454 cites W1990872391 @default.
• W2991151454 cites W1993220836 @default.
• W2991151454 cites W1993889646 @default.
• W2991151454 cites W1994724635 @default.
• W2991151454 cites W2002783887 @default.
• W2991151454 cites W2004361236 @default.
• W2991151454 cites W2008002430 @default.
• W2991151454 cites W2009659096 @default.
• W2991151454 cites W2011041694 @default.
• W2991151454 cites W2011306095 @default.
• W2991151454 cites W2011414645 @default.
• W2991151454 cites W2014808209 @default.
• W2991151454 cites W2016470397 @default.
• W2991151454 cites W2016676102 @default.
• W2991151454 cites W2017831280 @default.
• W2991151454 cites W2029906813 @default.
• W2991151454 cites W2032994377 @default.
• W2991151454 cites W2033987011 @default.
• W2991151454 cites W2037203209 @default.
• W2991151454 cites W2037647894 @default.
• W2991151454 cites W2039668681 @default.
• W2991151454 cites W2040166628 @default.
• W2991151454 cites W2040585119 @default.
• W2991151454 cites W2041964216 @default.
• W2991151454 cites W2044090829 @default.
• W2991151454 cites W2044219916 @default.
• W2991151454 cites W2044566850 @default.
• W2991151454 cites W2045707010 @default.
• W2991151454 cites W2045733321 @default.
• W2991151454 cites W2053479959 @default.
• W2991151454 cites W2056512090 @default.
• W2991151454 cites W2057919063 @default.
• W2991151454 cites W2062525835 @default.
• W2991151454 cites W2062530394 @default.
• W2991151454 cites W2065375190 @default.
• W2991151454 cites W2067267561 @default.
• W2991151454 cites W2067278559 @default.
• W2991151454 cites W2068966740 @default.
• W2991151454 cites W2069776467 @default.
• W2991151454 cites W2070221838 @default.
• W2991151454 cites W2071633415 @default.
• W2991151454 cites W2075807462 @default.
• W2991151454 cites W2076554399 @default.
• W2991151454 cites W2077047479 @default.
• W2991151454 cites W2080230029 @default.
• W2991151454 cites W2080426752 @default.
• W2991151454 cites W2080638151 @default.
• W2991151454 cites W2083985100 @default.
• W2991151454 cites W2084654069 @default.
• W2991151454 cites W2085702304 @default.
• W2991151454 cites W2086727474 @default.
• W2991151454 cites W2092112738 @default.
• W2991151454 cites W2092862627 @default.
• W2991151454 cites W2094170319 @default.
• W2991151454 cites W2094715296 @default.
• W2991151454 cites W2097018387 @default.
• W2991151454 cites W2099671309 @default.
• W2991151454 cites W2100390492 @default.
• W2991151454 cites W2104274085 @default.
• W2991151454 cites W2111425451 @default.
• W2991151454 cites W2119812304 @default.
• W2991151454 cites W2120690437 @default.
• W2991151454 cites W2128328936 @default.
• W2991151454 cites W2129470375 @default.
• W2991151454 cites W2137777366 @default.
• W2991151454 cites W2144078756 @default.

• next