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- W2991154501 abstract "Background: Bisphenol A (BPA) is an endocrine disrupting chemical found in canned food and other consumer products. BPA has been detected in human specimens throughout the world and at levels similar to those associated with adverse reproductive outcomes in animal models. Objective: To examine and compare the distribution of urinary BPA concentrations collected from partners of a male-female couple. Methods: A prospective, pre-conception cohort of couples (women 18–35, men 18–40) without known infertility were recruited in Utah beginning in early 2012. Recruitment is ongoing. Couples observed cervical mucus to identify an estimated day of ovulation (EDO) and fertile window. Participants collected first-morning urine samples beginning during the fertile window, after which men discontinued collecting but women collected for the remainder of the cycle. BPA was measured in each urine sample using quantitative liquid chromatography-tandem-mass spectrometry. Geometric means with 95% confidence intervals (CI) for BPA concentrations were calculated by taking the antilog of the mean of the natural log-transformed values. Differences in geometric mean by sex were tested using the Wilcoxon Test to account for daily repeated urines and the coupled, matched-pair design. Results: BPA was detected in 100% of samples at concentrations ?0.4ng/mL. Within-individual values varied several-fold from day-to-day. Preliminary results of 846 urine samples (636 female, 210 male) show a geometric mean of BPA as 2.72ng/mL (95% CI, 2.57–2.88) and median of 2.63ng/mL (interquartile range, 1.78ng/mL). Geometric mean BPA levels were higher among men (p=0.025) at 3.26ng/mL (95% CI, 2.90–3.65) compared to women at 2.57ng/mL (95% CI, 2.41–2.74). Conclusions: These preliminary findings suggest that BPA exposure is higher among men than women. The high daily variability suggests that single-day measurement is likely insufficient for exposure assessment." @default.
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- W2991154501 date "2013-09-19" @default.
- W2991154501 modified "2023-09-28" @default.
- W2991154501 title "Urinary Bisphenol A Concentrations Measured on Multiple Consecutive Days in a Prospective, Pre-conception Cohort" @default.
- W2991154501 doi "https://doi.org/10.1289/isee.2013.p-3-15-23" @default.
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