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- W2991201071 abstract "Transfer RNA-derived fragments (tRFs) are known to contribute to multiple illnesses, including cancers, viral infections, and age-related neurodegeneration. In this study, we used senescence-accelerated mouse prone 8 (SAMP8) as a model of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, and a control, the senescence-accelerated mouse resistant 1 (SAMR1) model, to comprehensively explore differences in tRF expression between them. We discovered 570 tRF transcripts among which eight were differentially expressed. We then obtained 110 potential target genes in a miRNA-like pattern. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation suggest that these target genes participate in a variety of brain functions; e.g., synapse formation (GO: 0045202) and the synaptic vesicle cycle pathway. We further assessed in detail those tRFs whose miRNA-like pattern was most likely to promote the progression of either Alzheimer's or Parkinson's disease, such as AS-tDR-011775 acting on Mobp and Park2. Our findings suggest the eight dysregulated tRFs we uncovered here may be beneficially exploited as potential diagnostic biomarkers and/or therapeutic targets to treat age-related brain diseases." @default.
- W2991201071 created "2019-12-05" @default.
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- W2991201071 date "2019-11-20" @default.
- W2991201071 modified "2023-10-15" @default.
- W2991201071 title "Identification of functional tRNA-derived fragments in senescence-accelerated mouse prone 8 brain" @default.
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- W2991201071 doi "https://doi.org/10.18632/aging.102471" @default.
- W2991201071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6914438" @default.
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