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- W2991201379 abstract ": Photoreceptor loss is a major cause of blindness around the world. Stem cell therapy offers a new strategy in retina degenerative disease. Retinal progenitors can be derived from embryonic stem cells (ESC) in vitro, but cannot be processed to a mature state. In addition, the adult recipient retina presents a very different environment than the photoreceptor precursor donor. : It seems that modulation of the recipient environment by ectopic development regulated growth factors for transplanted cells could generate efficient putative photoreceptors. The purpose of this review article was to investigate the signaling pathway of growth factors including: insulin-like growth factors (IGFs), fibroblast growth factors (FGF), Nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF), Taurin and Retinoic acid (RA) involved in the differentiation of neuroretina cell, like; photoreceptor and retinal progenitor cells. Given the results available in the related literature, the differentiation efficacy of ESCs toward the photoreceptor and retinal neurons and the important role of growth factors in activating signaling pathways such as Akt, Ras/Raf1/ and ERKs also inhibit the ASK1/JNK apoptosis pathway. Manipulating differentiated culture, growth factors can influence photoreceptor transplantation efficiency in retinal degenerative disease." @default.
- W2991201379 created "2019-12-05" @default.
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- W2991201379 creator A5049380536 @default.
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- W2991201379 creator A5077636826 @default.
- W2991201379 date "2020-04-24" @default.
- W2991201379 modified "2023-10-03" @default.
- W2991201379 title "Growth Factors as Tools in Photoreceptor Cell Regeneration and Vision Recovery" @default.
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- W2991201379 doi "https://doi.org/10.2174/1389450120666191121103831" @default.
- W2991201379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31755378" @default.
- W2991201379 hasPublicationYear "2020" @default.
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