FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991206768> ?p ?o ?g. }

• W2991206768 abstract "Alzheimer’s disease (AD) and type 2 diabetes (T2D) are among the most prevalent chronic diseases affecting the aging population. Extensive research evidence indicates that T2D is a well-established risk factor for AD, however, the molecular mechanisms underlying this association have not been fully elucidated. Furthermore, how T2D may contribute to the progression of AD is a subject of extensive investigation. In this study, we compared the blood transcriptome of patients with mild cognitive impairment (MCI), AD, and advanced AD to those afflicted with T2D to unveil shared and unique pathways and potential therapeutic targets. Blood transcriptomic analyses revealed a positive correlation between gene expression profiles of MCI, AD and T2D in 7 independent microarrays. Interestingly, gene expression profiles from women with advanced AD correlated negatively with T2D suggesting sex-specific differences in T2D as a risk factor for AD. Network and pathway analysis revealed that shared molecular networks between MCI and T2D were predominantly enriched in inflammation and infectious diseases whereas those networks shared between overt AD and T2D were involved in the phosphatidylinositol 3-kinase and protein kinase B/Akt (PI3K-AKT) signaling pathway, a major mediator of insulin signaling in the body. The PI3K-AKT signaling pathway became more significantly dysregulated in the advanced AD and T2D shared network. Furthermore, endocrine resistance and atherosclerosis pathways emerged as dysregulated pathways in the advanced AD and T2D shared network. Interestingly, network analysis of shared differentially expressed genes between children with T2D and MCI subjects identified forkhead box O3 (FOXO3) as a central transcriptional regulator suggesting it may be a potential therapeutic target for early intervention in AD. Collectively, these results suggest that T2D may be implicated at different stages of AD through different molecular pathways disrupted during the preclinical phase of AD and more advanced stages of the disease." @default.
• W2991206768 created "2019-12-05" @default.
• W2991206768 creator A5013859162 @default.
• W2991206768 creator A5052174741 @default.
• W2991206768 creator A5060343647 @default.
• W2991206768 date "2019-11-29" @default.
• W2991206768 modified "2023-10-16" @default.
• W2991206768 title "Transcriptomic and Network Analysis Highlight the Association of Diabetes at Different Stages of Alzheimer’s Disease" @default.
• W2991206768 cites W1563190123 @default.
• W2991206768 cites W1566270348 @default.
• W2991206768 cites W1566831845 @default.
• W2991206768 cites W1585782290 @default.
• W2991206768 cites W1710226705 @default.
• W2991206768 cites W1966591940 @default.
• W2991206768 cites W1972204550 @default.
• W2991206768 cites W1993553556 @default.
• W2991206768 cites W1995617021 @default.
• W2991206768 cites W2020267609 @default.
• W2991206768 cites W2022176071 @default.
• W2991206768 cites W2030360966 @default.
• W2991206768 cites W2031734589 @default.
• W2991206768 cites W2031791496 @default.
• W2991206768 cites W2034930763 @default.
• W2991206768 cites W2035762040 @default.
• W2991206768 cites W2040607104 @default.
• W2991206768 cites W2041947516 @default.
• W2991206768 cites W2055268621 @default.
• W2991206768 cites W2058381071 @default.
• W2991206768 cites W2067820229 @default.
• W2991206768 cites W2070901692 @default.
• W2991206768 cites W2071728536 @default.
• W2991206768 cites W2081533023 @default.
• W2991206768 cites W2081700231 @default.
• W2991206768 cites W2095847999 @default.
• W2991206768 cites W2099535442 @default.
• W2991206768 cites W2102528806 @default.
• W2991206768 cites W2102661493 @default.
• W2991206768 cites W2103717170 @default.
• W2991206768 cites W2104651320 @default.
• W2991206768 cites W2108557201 @default.
• W2991206768 cites W2114729479 @default.
• W2991206768 cites W2124759835 @default.
• W2991206768 cites W2127956785 @default.
• W2991206768 cites W2128007601 @default.
• W2991206768 cites W2134556872 @default.
• W2991206768 cites W2135148756 @default.
• W2991206768 cites W2148894404 @default.
• W2991206768 cites W2153767933 @default.
• W2991206768 cites W2156280702 @default.
• W2991206768 cites W2161964141 @default.
• W2991206768 cites W2163608581 @default.
• W2991206768 cites W2164563480 @default.
• W2991206768 cites W2165186407 @default.
• W2991206768 cites W2211614117 @default.
• W2991206768 cites W2265799967 @default.
• W2991206768 cites W2296092666 @default.
• W2991206768 cites W2327790265 @default.
• W2991206768 cites W2341089804 @default.
• W2991206768 cites W2516351771 @default.
• W2991206768 cites W2524246096 @default.
• W2991206768 cites W2589104144 @default.
• W2991206768 cites W2600899793 @default.
• W2991206768 cites W2618180582 @default.
• W2991206768 cites W2731000069 @default.
• W2991206768 cites W2734581387 @default.
• W2991206768 cites W2754782024 @default.
• W2991206768 cites W2756852269 @default.
• W2991206768 cites W2757100609 @default.
• W2991206768 cites W2767044835 @default.
• W2991206768 cites W2768823399 @default.
• W2991206768 cites W2803088409 @default.
• W2991206768 cites W2885532750 @default.
• W2991206768 cites W2888325257 @default.
• W2991206768 cites W2898209485 @default.
• W2991206768 cites W2922203379 @default.
• W2991206768 cites W2940623585 @default.
• W2991206768 cites W2942157380 @default.
• W2991206768 cites W2953594239 @default.
• W2991206768 cites W2953850763 @default.
• W2991206768 cites W4210821588 @default.
• W2991206768 cites W4235025907 @default.
• W2991206768 doi "https://doi.org/10.3389/fnins.2019.01273" @default.
• W2991206768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6895844" @default.
• W2991206768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31849586" @default.
• W2991206768 hasPublicationYear "2019" @default.
• W2991206768 type Work @default.
• W2991206768 sameAs 2991206768 @default.
• W2991206768 citedByCount "32" @default.
• W2991206768 countsByYear W29912067682020 @default.
• W2991206768 countsByYear W29912067682021 @default.
• W2991206768 countsByYear W29912067682022 @default.
• W2991206768 countsByYear W29912067682023 @default.
• W2991206768 crossrefType "journal-article" @default.
• W2991206768 hasAuthorship W2991206768A5013859162 @default.
• W2991206768 hasAuthorship W2991206768A5052174741 @default.
• W2991206768 hasAuthorship W2991206768A5060343647 @default.
• W2991206768 hasBestOaLocation W29912067681 @default.
• W2991206768 hasConcept C104317684 @default.
• W2991206768 hasConcept C112446052 @default.
• W2991206768 hasConcept C126322002 @default.

• next