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- W2991220130 abstract "Objective We aimed to examine arterial stiffness and vitamin K2 status in migraine subjects by comparison to controls. Background Migraine is a primary headache disorder that has been associated with an increased risk of cardiovascular events. Mechanisms underlying this increased risk, however, remain unclear. Vitamin K2 deficiency emerged as a cardiovascular risk factor, but vitamin K2 status has never been explored in migraine subjects. Design and Methods This is a case‐control, single‐center, observational study that includes a cohort of subjects with migraine and their age‐ and sex‐matched controls. Arterial stiffness was measured using carotid‐femoral pulse wave velocity (cfPWV). Dephosphorylated‐uncarboxylated matrix‐Gla‐protein (dp‐ucMGP) was used as a marker for vitamin K2 status. A propensity‐matched scoring method was used. Results A total of 146 patients (73 matched pairs) were included in this study, of whom 89% were women with a mean age of 31.9 ± 8.4 years. Compared with controls, migraine patients had statistically significantly higher mean cfPWV (7.2 ± 1.1 vs 6.4 ± 0.8 m/s, 95% confidence interval (CI) of mean difference [0.45, 1.08], P < .001), as well as higher dp‐ucMGP (454.3 ± 116.7 pmol/L vs 379.8 ± 126.6 pmol/L, 95% CI of mean difference [34.63, 114.31], P < .001). Higher cfPWV was associated with higher dp‐ucMGP concentrations only in the migraine with aura (MWA) group. Moreover, migraine subjects had a higher frequency of vitamin K2 deficiency (dp‐ucMGP ≥ 500 pmol/L) compared to controls, but this association was not statistically significant (23/73 [31.5%] vs 16/73 [21.9%], P = .193). Conclusions Individuals with migraine have worse indices of arterial stiffness as compared with their age‐ and sex‐matched control subjects. This increase in arterial stiffness is associated with an increase in markers of vitamin K2 deficiency in the MWA group." @default.
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- W2991220130 date "2019-11-25" @default.
- W2991220130 modified "2023-10-01" @default.
- W2991220130 title "Vitamin K2 Status and Arterial Stiffness Among Untreated Migraine Patients: A Case‐Control Study" @default.
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- W2991220130 doi "https://doi.org/10.1111/head.13715" @default.
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