FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991223195> ?p ?o ?g. }

• W2991223195 abstract "Abstract Previous etiologic studies have indicated that both environmental and genetic factors play important roles in the occurrence and development of chronic Achilles tendinopathy (AT). A recent study documented the results of the largest genome-wide association study for chronic AT to date, indicating that MPP7, TIMP2 and CASP8 may be involved in the occurrence and development of chronic AT. In this study, we aimed to investigate whether MPP7 , TIMP2 and CASP8 were associated with susceptibility to chronic AP in a Han Chinese population. A total of 3,680 study subjects comprised 1,288 chronic AT cases, and 2,392 healthy controls were recruited. Forty-four tag SNPs (7 from CASP8 , 20 from MPP7 , and 17 from TIMP2 ) were genotyped in the study. Genetic association analyses were performed at both single marker and haplotype levels. Functional consequences of significant SNPs were examined in the RegulomeDB and GTEx databases. Two SNPs, SNP rs1937810 (OR [95%CI] = 1.20 [1.09–1.32], χ 2 = 13.50, P = 0.0002) in MPP7 and rs4789932 (OR [95%CI] = 1.24 [1.12–1.37], χ 2 = 17.98, P = 2.23 × 10 −5 ) in TIMP2 , were significantly associated with chronic AT. Significant eQTL signals for SNP rs4789932 on TIMP2 were identified in human heart and artery tissues. Our results provide further supportive evidence for the association of the TIMP2 and MPP7 genes with chronic AT, which supports important roles for TIMP2 and MPP7 in the etiology of chronic AT, adding to the current understanding of the susceptibility of chronic AT." @default.
• W2991223195 created "2019-12-05" @default.
• W2991223195 creator A5004715600 @default.
• W2991223195 creator A5006816148 @default.
• W2991223195 creator A5026978058 @default.
• W2991223195 creator A5042860453 @default.
• W2991223195 creator A5066599847 @default.
• W2991223195 creator A5072909687 @default.
• W2991223195 date "2019-11-26" @default.
• W2991223195 modified "2023-10-18" @default.
• W2991223195 title "Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy" @default.
• W2991223195 cites W1872514198 @default.
• W2991223195 cites W1913410150 @default.
• W2991223195 cites W1949757104 @default.
• W2991223195 cites W1992071972 @default.
• W2991223195 cites W1992133790 @default.
• W2991223195 cites W1995339205 @default.
• W2991223195 cites W2008280378 @default.
• W2991223195 cites W2011404502 @default.
• W2991223195 cites W2028277256 @default.
• W2991223195 cites W2029710824 @default.
• W2991223195 cites W2030835221 @default.
• W2991223195 cites W2033056433 @default.
• W2991223195 cites W2053072677 @default.
• W2991223195 cites W2055801225 @default.
• W2991223195 cites W2094450062 @default.
• W2991223195 cites W2097937302 @default.
• W2991223195 cites W2099085143 @default.
• W2991223195 cites W2109878385 @default.
• W2991223195 cites W2113858336 @default.
• W2991223195 cites W2114330361 @default.
• W2991223195 cites W2115965890 @default.
• W2991223195 cites W2117757724 @default.
• W2991223195 cites W2125858955 @default.
• W2991223195 cites W2138754184 @default.
• W2991223195 cites W2152664025 @default.
• W2991223195 cites W2160063494 @default.
• W2991223195 cites W2162530578 @default.
• W2991223195 cites W2234521596 @default.
• W2991223195 cites W2282141885 @default.
• W2991223195 cites W2323812506 @default.
• W2991223195 cites W2341972066 @default.
• W2991223195 cites W2469993515 @default.
• W2991223195 cites W2475363254 @default.
• W2991223195 cites W2508728551 @default.
• W2991223195 cites W2555268891 @default.
• W2991223195 cites W2557263742 @default.
• W2991223195 cites W2602753219 @default.
• W2991223195 cites W2745852771 @default.
• W2991223195 cites W2766396805 @default.
• W2991223195 cites W2891148720 @default.
• W2991223195 cites W2894783571 @default.
• W2991223195 cites W2897205278 @default.
• W2991223195 cites W2952170213 @default.
• W2991223195 cites W4231545500 @default.
• W2991223195 cites W4252613300 @default.
• W2991223195 doi "https://doi.org/10.1038/s41598-019-54097-y" @default.
• W2991223195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6879592" @default.
• W2991223195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31772230" @default.
• W2991223195 hasPublicationYear "2019" @default.
• W2991223195 type Work @default.
• W2991223195 sameAs 2991223195 @default.
• W2991223195 citedByCount "9" @default.
• W2991223195 countsByYear W29912231952020 @default.
• W2991223195 countsByYear W29912231952021 @default.
• W2991223195 countsByYear W29912231952022 @default.
• W2991223195 countsByYear W29912231952023 @default.
• W2991223195 crossrefType "journal-article" @default.
• W2991223195 hasAuthorship W2991223195A5004715600 @default.
• W2991223195 hasAuthorship W2991223195A5006816148 @default.
• W2991223195 hasAuthorship W2991223195A5026978058 @default.
• W2991223195 hasAuthorship W2991223195A5042860453 @default.
• W2991223195 hasAuthorship W2991223195A5066599847 @default.
• W2991223195 hasAuthorship W2991223195A5072909687 @default.
• W2991223195 hasBestOaLocation W29912231951 @default.
• W2991223195 hasConcept C104317684 @default.
• W2991223195 hasConcept C106208931 @default.
• W2991223195 hasConcept C135763542 @default.
• W2991223195 hasConcept C139275648 @default.
• W2991223195 hasConcept C142724271 @default.
• W2991223195 hasConcept C153209595 @default.
• W2991223195 hasConcept C2778911562 @default.
• W2991223195 hasConcept C2780105995 @default.
• W2991223195 hasConcept C2908647359 @default.
• W2991223195 hasConcept C54355233 @default.
• W2991223195 hasConcept C60644358 @default.
• W2991223195 hasConcept C71924100 @default.
• W2991223195 hasConcept C86803240 @default.
• W2991223195 hasConcept C99454951 @default.
• W2991223195 hasConceptScore W2991223195C104317684 @default.
• W2991223195 hasConceptScore W2991223195C106208931 @default.
• W2991223195 hasConceptScore W2991223195C135763542 @default.
• W2991223195 hasConceptScore W2991223195C139275648 @default.
• W2991223195 hasConceptScore W2991223195C142724271 @default.
• W2991223195 hasConceptScore W2991223195C153209595 @default.
• W2991223195 hasConceptScore W2991223195C2778911562 @default.
• W2991223195 hasConceptScore W2991223195C2780105995 @default.
• W2991223195 hasConceptScore W2991223195C2908647359 @default.
• W2991223195 hasConceptScore W2991223195C54355233 @default.
• W2991223195 hasConceptScore W2991223195C60644358 @default.

• next