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- W2991270167 abstract "Introduction: Numerous asthma patients remain uncontrolled on guidelines recommended therapies. We examined real-life asthma control in Japanese patients prescribed with ICS/LABA Methods: This retrospective study enrolled patients (≥12yrs) with ≥2 asthma diagnoses, newly initiated medium- or high-dose ICS/LABA as per Japan asthma guidelines between 1 April 2009 and 31 March 2015, using Japan Medical Data Center Claims. Primary objective: to identify % of patients with sub-optimal asthma control in 1-yr following initial ICS/LABA prescription. Sub-optimal control was defined by onset of any of following: exacerbation, treatment step-up or above threshold SABA use. Secondary objectives: demographic and clinical predictors of sub-optimal control. Patient adherence and inhaler technique were not available for analysis as predictors of control Results: In medium-dose (N=24,937) and high-dose (N=8,661) ICS/LABA cohorts, 23% and 21% patients were sub-optimally controlled, respectively. In both cohorts, treatment step-up and exacerbation were most common indicators for loss of asthma control. Predictors of sub-optimal control included exacerbation history, comorbidities and female sex (Table) Conclusions: Despite universal health access in Japan, disease control appears sub-optimal in over 20% patients with persistent asthma, highlighting unmet medical needs and opportunity for novel therapies in these patients" @default.
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- W2991270167 date "2019-09-28" @default.
- W2991270167 modified "2023-09-23" @default.
- W2991270167 title "Sub-optimal asthma control with medium- or high-dose ICS/LABA: a retrospective cohort study from Japan claims database" @default.
- W2991270167 doi "https://doi.org/10.1183/13993003.congress-2019.pa2552" @default.
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