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- W2991301770 abstract "The Cover Feature shows a chemist who is juggling O-silylated hydroxamic acids, in the presence of NEt3 and trifluoromethanesulfonic anhydride (Tf2O), to allow 1,3-dipolar cycloaddition reaction with alkynyl dipolarophiles and regioselective formation of 3,5-disubstituted isoxazole. Cycloaddition takes place between the alkyne and nitrile oxide, generated in-situ from the O-silylated hydroxamic acid previously developed by the Carreira group. Juggling has been selected for illustration considering the straightforward, practical and efficient strategy which we have applied and optimized towards the regioselective synthesis of 3,5-disubstituted isoxazoles. More information can be found in the Full Paper by D. Bonifazi et al." @default.
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- W2991301770 date "2019-11-22" @default.
- W2991301770 modified "2023-09-28" @default.
- W2991301770 title "Cover Feature: Synthesis of 3,5-Disubstituted Isoxazoles through a 1,3-Dipolar Cycloaddition Reaction between Alkynes and Nitrile Oxides Generated from O -Silylated Hydroxamic Acidss (Eur. J. Org. Chem. 44/2019)" @default.
- W2991301770 doi "https://doi.org/10.1002/ejoc.201901634" @default.
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