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• W2991303902 abstract "Infection is a major cause of mortality and morbidity among burn patients. An effective measure to reduce infection is routine monitoring of bacterial infection and antimicrobial susceptibility patterns at the burn unit. This will help to create a burn centre-specific empirical antibiotic therapy protocol. A retrospective, descriptive study was conducted at the Cipto Mangunkusumo Hospital (RSCM) Burn Unit between September-November 2016. Data regarding bacterial culture isolates, antimicrobial susceptibility spectrum, and the number of burn patients diagnosed with sepsis were collected. There were 36 patients with positive bacterial cultures, with the isolates changing continuously between Klebsiella pneumonia (17%), Pseudomonas Aeruginosa (12%) and Acinetobacter baumannii (11%). High resistance was found for 10 antimicrobials, particularly cephalosporins. The three bacteria were only sensitive to carbapenem, aminoglycosides and tigecycline. Fourteen patients were diagnosed with sepsis (38.9%), 10 died. Two major sepsis-causing bacteria were P. aeruginosa (33.3%) and K. pneumoniae (28.9%). Bacterial isolates in our setting changed every month. Almost all bacterial isolates are multi-drug resistant, highly resistant to the empirical therapy given (ceftriaxone), leading to outbreaks of sepsis and increased mortality rates. Carbapenem (imipenem, meropenem and doripenem) and aminoglycosides (amikacin) combination was the selected empirical therapy.L’infection est une cause majeure de morbi-mortalité chez les brûlés. Une des mesures de contrôle est le suivi microbiologique systématique dans l’unité, permettant de définir l’antibiothérapie probabiliste à ce niveau. Une étude rétrospective a été réalisée entre septembre et novembre 2016 dans le CTB de l’hôpital Cipto Mangukusumo (HCM, Indonésie). Les données concernant les patients infectés, les bactéries en cause et leur antibiogramme ont été colligées. Des résultats bactériologiques positifs ont été retrouvés chez 36 patients, 14 d’entre eux étant septiques (10 décès). On trouvait le plus souvent Klebsiella pneumoniæ (17%), Pseudomonas æruginosa (12%) ou Acinetobacter baumannii (11%), sans série d’isolement de l’une ou l’autre bactérie. La résistance était très fréquente vis-à-vis de 10 antibiotiques parmi lesquels les céphalosporines, les trois principales bactéries n’étant régulièrement sensibles qu’au carbapénèmes, aux aminosides et à la tigécycline. Pseudomonas æruginosa (33,3%) et Klebsiella pneumoniæ (28,9%) étaient les principaux responsables de sepsis. La répartition de l’écologie variait en permanence. Presque toutes les bactéries résistait à le ceftriaxone, qui était jusqu’alors la base de l’antibiothérapie probabiliste, avec pour conséquence une épidémie septique et une surmortalité. Nous avons alors choisi une antibiothérapie probabiliste basée sur les carbapénèmes (imipénème, méropénème, doripénème) et l’amikacine." @default.
• W2991303902 created "2019-12-05" @default.
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• W2991303902 date "2017-06-30" @default.
• W2991303902 modified "2023-09-27" @default.
• W2991303902 title "Bacterial and antimicrobial susceptibility profile and the prevalence of sepsis among burn patients at the burn unit of Cipto Mangunkusumo Hospital." @default.
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• W2991303902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5627547" @default.
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