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- W2991313877 abstract "Introduction: In Spain, the prevalence of severe persistent asthma is approximately 4-5% of the total asthma patients. Eosinophilic asthma patients represent 25% of these patients with severe persistent asthma. Mepolizumab is an effective treatment for these patients in reduction of systemic glucocorticoids’ dose and severe exacerbations. We aim to analyze clinical and functional efficacy of mepolizumab in our asthma unit uncontrolled patients. Methods: A retrospective observational study was performed in our asthma unit uncontrolled patients treated with mepolizumab from January 2017 to September 2018. Demographic and clinical variables were recorded. We analyzed systemic glucocorticoids´ dose, %FEV1 and the number of total exacerbations in the previous year of mepolizumab treatment. Results: 16 patients were included, 81.3% females (mean age 55 ± 11 years; mean age at diagnosis 30 ± 13 years). The main reason to start the treatment with mepolizumab was to reduce systemic glucocorticoids’ dose (SG). 11 patients required daily SG to maintain asthma control and 7 of them could achieve total cessation. Besides, the other 4 patients got SG dose reduction (mean dose before 8.8 ± 8.6 and after 6.56 ± 5.71; p Conclusions: In patient requiring daily SG to maintain asthma control, mepolizumab had a significant total cessation of SG, reduced exacerbations, control of asthma symptoms and improved lung function." @default.
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- W2991313877 date "2019-09-28" @default.
- W2991313877 modified "2023-09-24" @default.
- W2991313877 title "Experience with Mepolizumab in a cohort of patients with eosinophilic severe persistent asthma" @default.
- W2991313877 doi "https://doi.org/10.1183/13993003.congress-2019.pa2520" @default.
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