Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991314293> ?p ?o ?g. }
- W2991314293 endingPage "104100" @default.
- W2991314293 startingPage "104100" @default.
- W2991314293 abstract "Val-Phe-Val-Arg-Asn (VFVRN) has been identified and screened from lipid-lowering chickpea peptides (ChPs) previously. This work explored its lipid-lowering mechanisms by using a high-fat diet C57BL/6J mice model and 3T3-L1 preadipocyte cell model. Administration of VFVRN to hyperlipidemic mice significantly decreased the levels of total cholesterol (TC) and total triglyceride (TG) in liver and serum (P < 0.05), and increased the fecal triglyceride excretions. The expressions of sterol regulatory element-binding protein (SREBP)-2, liver X receptor (LXR)α, peroxisome proliferator-activated receptors (PPAR)α and their related target genes were regulated via AMP-activated protein kinase (p-AMPK) pathway in liver. Compared with model group, the levels of PPARα and PPARγ in 10 mg/kg VFVRN group were up-regulated by 36.96% and 36.49% in adipose tissues, while LXRα and ATP binding cassette G5/8 transporters (ABGC5/8) were lowered by 87.26% and 145% in small intestine respectively. Moreover, VFVRN promoted 3T3-L1 preadipocyte apoptosis by regulating the expressions of BaX, Caspase-3 and Bcl-2." @default.
- W2991314293 created "2019-12-05" @default.
- W2991314293 creator A5004410070 @default.
- W2991314293 creator A5007536117 @default.
- W2991314293 creator A5019771719 @default.
- W2991314293 creator A5070098548 @default.
- W2991314293 creator A5091716767 @default.
- W2991314293 date "2020-10-01" @default.
- W2991314293 modified "2023-10-16" @default.
- W2991314293 title "Hypolipidemic effects and mechanisms of Val-Phe-Val-Arg-Asn in C57BL/6J mice and 3T3-L1 cell models" @default.
- W2991314293 cites W1125737316 @default.
- W2991314293 cites W1501432546 @default.
- W2991314293 cites W1528594194 @default.
- W2991314293 cites W1589324397 @default.
- W2991314293 cites W1975561886 @default.
- W2991314293 cites W1994457713 @default.
- W2991314293 cites W2000821877 @default.
- W2991314293 cites W2001079924 @default.
- W2991314293 cites W2002175910 @default.
- W2991314293 cites W2009828261 @default.
- W2991314293 cites W2016285095 @default.
- W2991314293 cites W2017993044 @default.
- W2991314293 cites W2019560452 @default.
- W2991314293 cites W2042726523 @default.
- W2991314293 cites W2046425824 @default.
- W2991314293 cites W2051215268 @default.
- W2991314293 cites W2052563704 @default.
- W2991314293 cites W2062560800 @default.
- W2991314293 cites W2063311807 @default.
- W2991314293 cites W2063801481 @default.
- W2991314293 cites W2070779294 @default.
- W2991314293 cites W2076263820 @default.
- W2991314293 cites W2078328700 @default.
- W2991314293 cites W2078575160 @default.
- W2991314293 cites W2079783565 @default.
- W2991314293 cites W2086482588 @default.
- W2991314293 cites W2086525782 @default.
- W2991314293 cites W2094329102 @default.
- W2991314293 cites W2112316124 @default.
- W2991314293 cites W2113224591 @default.
- W2991314293 cites W2116584510 @default.
- W2991314293 cites W2121244624 @default.
- W2991314293 cites W2125090169 @default.
- W2991314293 cites W2126736297 @default.
- W2991314293 cites W2130117548 @default.
- W2991314293 cites W2155730665 @default.
- W2991314293 cites W2157006095 @default.
- W2991314293 cites W2168346186 @default.
- W2991314293 cites W2169679878 @default.
- W2991314293 cites W2258145458 @default.
- W2991314293 cites W2313240267 @default.
- W2991314293 cites W2344572401 @default.
- W2991314293 cites W2346158578 @default.
- W2991314293 cites W2385851610 @default.
- W2991314293 cites W2472281584 @default.
- W2991314293 cites W2577934204 @default.
- W2991314293 cites W2607150659 @default.
- W2991314293 cites W2696298149 @default.
- W2991314293 cites W2770600921 @default.
- W2991314293 cites W2811270906 @default.
- W2991314293 cites W2910717197 @default.
- W2991314293 cites W3011060010 @default.
- W2991314293 cites W4247935329 @default.
- W2991314293 doi "https://doi.org/10.1016/j.jff.2020.104100" @default.
- W2991314293 hasPublicationYear "2020" @default.
- W2991314293 type Work @default.
- W2991314293 sameAs 2991314293 @default.
- W2991314293 citedByCount "12" @default.
- W2991314293 countsByYear W29913142932021 @default.
- W2991314293 countsByYear W29913142932022 @default.
- W2991314293 countsByYear W29913142932023 @default.
- W2991314293 crossrefType "journal-article" @default.
- W2991314293 hasAuthorship W2991314293A5004410070 @default.
- W2991314293 hasAuthorship W2991314293A5007536117 @default.
- W2991314293 hasAuthorship W2991314293A5019771719 @default.
- W2991314293 hasAuthorship W2991314293A5070098548 @default.
- W2991314293 hasAuthorship W2991314293A5091716767 @default.
- W2991314293 hasBestOaLocation W29913142931 @default.
- W2991314293 hasConcept C104317684 @default.
- W2991314293 hasConcept C126322002 @default.
- W2991314293 hasConcept C127078168 @default.
- W2991314293 hasConcept C134018914 @default.
- W2991314293 hasConcept C167400880 @default.
- W2991314293 hasConcept C170493617 @default.
- W2991314293 hasConcept C171089720 @default.
- W2991314293 hasConcept C184235292 @default.
- W2991314293 hasConcept C185592680 @default.
- W2991314293 hasConcept C187345961 @default.
- W2991314293 hasConcept C190283241 @default.
- W2991314293 hasConcept C2778163477 @default.
- W2991314293 hasConcept C2778718757 @default.
- W2991314293 hasConcept C2778913445 @default.
- W2991314293 hasConcept C2780124434 @default.
- W2991314293 hasConcept C55493867 @default.
- W2991314293 hasConcept C63932345 @default.
- W2991314293 hasConcept C71924100 @default.
- W2991314293 hasConcept C85051948 @default.
- W2991314293 hasConcept C86339819 @default.