Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991316996> ?p ?o ?g. }
- W2991316996 endingPage "463" @default.
- W2991316996 startingPage "451" @default.
- W2991316996 abstract "Abstract Recent evidence revealed that lysophosphatidic acid receptor 4 (LPAR4) plays a role in osteogenesis and bone remodeling in mice. However, the molecular mechanism by which LPAR4 controls osteogenic and adipogenic differentiation of mesenchymal progenitor cells remains pending. In the current study, our data showed that Lpar4 was expressed in bone and adipose tissue and the expression increased during osteoblast and adipocyte differentiation. Lpar4 overexpression in stromal ST2 and preosteoblastic MC3T3-E1 cells inhibited osteogenic differentiation. By contrast, Lpar4 overexpression in ST2 and mesenchymal C3H10T1/2 cells enhanced adipogenic differentiation. Conversely, depletion of endogenous Lpar4 in the progenitor cells induced osteogenic differentiation and inhibited adipogenic differentiation. Furthermore, enhanced osteoblast differentiation and alleviated fat accumulation were observed in marrow of mice after in vivo transfection of Lpar4 siRNA. Mechanism investigations revealed that LPAR4 inhibited the activation of ras homolog family member A (RhoA)/Rho-associated kinases 1 (ROCK1) and canonical Wnt signal pathways. ROCK1 was shown to be able to activate Wnt/β-catenin pathway. We further demonstrated that the overexpression of ROCK1 stimulated osteogenic differentiation and restrained adipogenic differentiation from stromal progenitor cells. Moreover, overexpression of ROCK1 attenuated the inhibition of osteogenic differentiation by LPAR4. The current study has provided evidences demonstrating that RhoA/ROCK1 activates β-catenin signaling to promote osteogenic differentiation and conversely restrain adipogenic differentiation. The inactivation of RhoA/ROCK1/β-catenin signaling is involved in LPAR4 regulation of the directional differentiation of marrow stromal progenitor cells." @default.
- W2991316996 created "2019-12-05" @default.
- W2991316996 creator A5008037802 @default.
- W2991316996 creator A5013787702 @default.
- W2991316996 creator A5019573704 @default.
- W2991316996 creator A5030121451 @default.
- W2991316996 creator A5052675433 @default.
- W2991316996 creator A5073064156 @default.
- W2991316996 creator A5084900138 @default.
- W2991316996 date "2019-12-14" @default.
- W2991316996 modified "2023-10-15" @default.
- W2991316996 title "Lysophosphatidic acid receptor 4 regulates osteogenic and adipogenic differentiation of progenitor cells via inactivation of RhoA/ROCK1/β-catenin signaling" @default.
- W2991316996 cites W1531820450 @default.
- W2991316996 cites W1968754797 @default.
- W2991316996 cites W1976260946 @default.
- W2991316996 cites W1984178317 @default.
- W2991316996 cites W1992203600 @default.
- W2991316996 cites W1992365461 @default.
- W2991316996 cites W1994596418 @default.
- W2991316996 cites W1996852865 @default.
- W2991316996 cites W2002697510 @default.
- W2991316996 cites W2008705000 @default.
- W2991316996 cites W2014103703 @default.
- W2991316996 cites W2032722121 @default.
- W2991316996 cites W2066482548 @default.
- W2991316996 cites W2085046768 @default.
- W2991316996 cites W2094907909 @default.
- W2991316996 cites W2122367477 @default.
- W2991316996 cites W2128977804 @default.
- W2991316996 cites W2144023435 @default.
- W2991316996 cites W2154894697 @default.
- W2991316996 cites W2155233266 @default.
- W2991316996 cites W2155610392 @default.
- W2991316996 cites W2155918296 @default.
- W2991316996 cites W2159108889 @default.
- W2991316996 cites W2159623504 @default.
- W2991316996 cites W2162676753 @default.
- W2991316996 cites W2165292725 @default.
- W2991316996 cites W2269475172 @default.
- W2991316996 cites W2512377627 @default.
- W2991316996 cites W2568446594 @default.
- W2991316996 cites W2597274407 @default.
- W2991316996 cites W2745155021 @default.
- W2991316996 cites W2779753586 @default.
- W2991316996 cites W2793880258 @default.
- W2991316996 cites W2889757347 @default.
- W2991316996 cites W2897865922 @default.
- W2991316996 cites W2904733946 @default.
- W2991316996 cites W2904936422 @default.
- W2991316996 cites W2912826725 @default.
- W2991316996 cites W2914305568 @default.
- W2991316996 doi "https://doi.org/10.1002/stem.3128" @default.
- W2991316996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31778241" @default.
- W2991316996 hasPublicationYear "2019" @default.
- W2991316996 type Work @default.
- W2991316996 sameAs 2991316996 @default.
- W2991316996 citedByCount "10" @default.
- W2991316996 countsByYear W29913169962020 @default.
- W2991316996 countsByYear W29913169962021 @default.
- W2991316996 countsByYear W29913169962022 @default.
- W2991316996 countsByYear W29913169962023 @default.
- W2991316996 crossrefType "journal-article" @default.
- W2991316996 hasAuthorship W2991316996A5008037802 @default.
- W2991316996 hasAuthorship W2991316996A5013787702 @default.
- W2991316996 hasAuthorship W2991316996A5019573704 @default.
- W2991316996 hasAuthorship W2991316996A5030121451 @default.
- W2991316996 hasAuthorship W2991316996A5052675433 @default.
- W2991316996 hasAuthorship W2991316996A5073064156 @default.
- W2991316996 hasAuthorship W2991316996A5084900138 @default.
- W2991316996 hasBestOaLocation W29913169961 @default.
- W2991316996 hasConcept C104317684 @default.
- W2991316996 hasConcept C122927707 @default.
- W2991316996 hasConcept C133717845 @default.
- W2991316996 hasConcept C137620995 @default.
- W2991316996 hasConcept C148738053 @default.
- W2991316996 hasConcept C16930146 @default.
- W2991316996 hasConcept C170493617 @default.
- W2991316996 hasConcept C198826908 @default.
- W2991316996 hasConcept C201750760 @default.
- W2991316996 hasConcept C202751555 @default.
- W2991316996 hasConcept C2776661833 @default.
- W2991316996 hasConcept C2777093181 @default.
- W2991316996 hasConcept C2778260815 @default.
- W2991316996 hasConcept C28328180 @default.
- W2991316996 hasConcept C502942594 @default.
- W2991316996 hasConcept C55493867 @default.
- W2991316996 hasConcept C62478195 @default.
- W2991316996 hasConcept C86803240 @default.
- W2991316996 hasConcept C95444343 @default.
- W2991316996 hasConceptScore W2991316996C104317684 @default.
- W2991316996 hasConceptScore W2991316996C122927707 @default.
- W2991316996 hasConceptScore W2991316996C133717845 @default.
- W2991316996 hasConceptScore W2991316996C137620995 @default.
- W2991316996 hasConceptScore W2991316996C148738053 @default.
- W2991316996 hasConceptScore W2991316996C16930146 @default.
- W2991316996 hasConceptScore W2991316996C170493617 @default.
- W2991316996 hasConceptScore W2991316996C198826908 @default.
- W2991316996 hasConceptScore W2991316996C201750760 @default.