FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991336378> ?p ?o ?g. }

• W2991336378 endingPage "292" @default.
• W2991336378 startingPage "283" @default.
• W2991336378 abstract "Airway hyperresponsiveness (AHR) often defines asthma. Murine allergic airway disease (AAD), like human eosinophilic asthma, is characterized by AHR, eosinophilia, goblet cell metaplasia (GCM), smooth muscle hypercontractility, and increased production of IL-4 and IL-13-cytokines that induce these characteristics by binding to the IL-4Rα chain. We evaluated the epithelial and smooth muscle IL-4Rα-dependent contributions to AHR of BALB/c mice that possessed 0-2 functional IL-4Rα alleles and had airway disease induced by house dust mite extract (HDM) or exogenous IL-13. Two functional IL-4Rα alleles were required for maximal AHR, while only one functional allele was required for maximal GCM and systemic IL-4/IL-13 levels. Deletion of IL-4Rα from both smooth muscle and epithelial cells inhibited AHR >83% in mice with two functional IL-4Rα alleles. In mice with one functional IL-4Rα allele, selective epithelial cell IL-4Rα deletion maximally inhibited AHR, while selective smooth muscle IL-4Rα deletion decreased IL-13-induced, but not HDM-induced, AHR. Less IL-4Rα signaling is required to maximize the epithelial cell contribution to AHR compared to the smooth muscle contribution to AHR. In addition, epithelial cell responses to IL-4/IL-13 can increase the IL-4Rα-dependent smooth muscle contribution to AHR. These findings carry increasing relevance as IL-4Rα-targeted therapy is administered to human asthmatics." @default.
• W2991336378 created "2019-12-05" @default.
• W2991336378 creator A5006100582 @default.
• W2991336378 creator A5010916998 @default.
• W2991336378 creator A5036569483 @default.
• W2991336378 date "2019-11-19" @default.
• W2991336378 modified "2023-10-15" @default.
• W2991336378 title "IL-4Rα expression by airway epithelium and smooth muscle accounts for nearly all airway hyperresponsiveness in murine allergic airway disease" @default.
• W2991336378 cites W151793644 @default.
• W2991336378 cites W1568910239 @default.
• W2991336378 cites W1601600505 @default.
• W2991336378 cites W1604832955 @default.
• W2991336378 cites W1700538518 @default.
• W2991336378 cites W1845629018 @default.
• W2991336378 cites W1913356655 @default.
• W2991336378 cites W1918582126 @default.
• W2991336378 cites W1930202916 @default.
• W2991336378 cites W1972624864 @default.
• W2991336378 cites W1977885071 @default.
• W2991336378 cites W1988128973 @default.
• W2991336378 cites W1995299599 @default.
• W2991336378 cites W1997822779 @default.
• W2991336378 cites W2014273697 @default.
• W2991336378 cites W2042630141 @default.
• W2991336378 cites W2061808825 @default.
• W2991336378 cites W2072254837 @default.
• W2991336378 cites W2074364115 @default.
• W2991336378 cites W2114967319 @default.
• W2991336378 cites W2124566107 @default.
• W2991336378 cites W2125805192 @default.
• W2991336378 cites W2128141544 @default.
• W2991336378 cites W2129536790 @default.
• W2991336378 cites W2132159107 @default.
• W2991336378 cites W2141990440 @default.
• W2991336378 cites W2142297198 @default.
• W2991336378 cites W2146671478 @default.
• W2991336378 cites W2147307935 @default.
• W2991336378 cites W2167829087 @default.
• W2991336378 cites W2169142991 @default.
• W2991336378 cites W2734737270 @default.
• W2991336378 cites W2752706812 @default.
• W2991336378 cites W2768643302 @default.
• W2991336378 cites W2769481548 @default.
• W2991336378 cites W2803941918 @default.
• W2991336378 cites W2805002966 @default.
• W2991336378 cites W2885531946 @default.
• W2991336378 cites W2897894071 @default.
• W2991336378 cites W2905049649 @default.
• W2991336378 cites W2908910593 @default.
• W2991336378 cites W2918664038 @default.
• W2991336378 cites W641499368 @default.
• W2991336378 cites W657751950 @default.
• W2991336378 doi "https://doi.org/10.1038/s41385-019-0232-7" @default.
• W2991336378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7641252" @default.
• W2991336378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31745261" @default.
• W2991336378 hasPublicationYear "2019" @default.
• W2991336378 type Work @default.
• W2991336378 sameAs 2991336378 @default.
• W2991336378 citedByCount "14" @default.
• W2991336378 countsByYear W29913363782020 @default.
• W2991336378 countsByYear W29913363782021 @default.
• W2991336378 countsByYear W29913363782022 @default.
• W2991336378 countsByYear W29913363782023 @default.
• W2991336378 crossrefType "journal-article" @default.
• W2991336378 hasAuthorship W2991336378A5006100582 @default.
• W2991336378 hasAuthorship W2991336378A5010916998 @default.
• W2991336378 hasAuthorship W2991336378A5036569483 @default.
• W2991336378 hasBestOaLocation W29913363781 @default.
• W2991336378 hasConcept C105922876 @default.
• W2991336378 hasConcept C141071460 @default.
• W2991336378 hasConcept C142724271 @default.
• W2991336378 hasConcept C191732599 @default.
• W2991336378 hasConcept C203014093 @default.
• W2991336378 hasConcept C207480886 @default.
• W2991336378 hasConcept C2776042228 @default.
• W2991336378 hasConcept C2778166374 @default.
• W2991336378 hasConcept C2778690821 @default.
• W2991336378 hasConcept C2780510475 @default.
• W2991336378 hasConcept C32046619 @default.
• W2991336378 hasConcept C529295009 @default.
• W2991336378 hasConcept C71924100 @default.
• W2991336378 hasConcept C86803240 @default.
• W2991336378 hasConcept C87568996 @default.
• W2991336378 hasConceptScore W2991336378C105922876 @default.
• W2991336378 hasConceptScore W2991336378C141071460 @default.
• W2991336378 hasConceptScore W2991336378C142724271 @default.
• W2991336378 hasConceptScore W2991336378C191732599 @default.
• W2991336378 hasConceptScore W2991336378C203014093 @default.
• W2991336378 hasConceptScore W2991336378C207480886 @default.
• W2991336378 hasConceptScore W2991336378C2776042228 @default.
• W2991336378 hasConceptScore W2991336378C2778166374 @default.
• W2991336378 hasConceptScore W2991336378C2778690821 @default.
• W2991336378 hasConceptScore W2991336378C2780510475 @default.
• W2991336378 hasConceptScore W2991336378C32046619 @default.
• W2991336378 hasConceptScore W2991336378C529295009 @default.
• W2991336378 hasConceptScore W2991336378C71924100 @default.
• W2991336378 hasConceptScore W2991336378C86803240 @default.
• W2991336378 hasConceptScore W2991336378C87568996 @default.

• next