FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991353018> ?p ?o ?g. }

• W2991353018 abstract "Background Nasopharyngeal carcinoma (NPC) is endemic in East Asia but rare in the western world. Programmed death ligand 1 (PD-L1) expression on NPC correlates with clinical outcomes. However, data for Caucasian NPC patients are missing. Thus, we performed this retrospective analysis for investigating the potential association of immune checkpoint protein expression with outcome parameters in Caucasian NPC patients. Methods Fifty-five patients with NPC treated between 1993 and 2018 at the Medical University of Vienna were identified. After the exclusion of Asian patients, data on baseline demographic, tumor stage, overall survival (OS), and disease-free survival (DFS) of 30 patients were analyzed. Their tumor samples were stained and scored (low vs. high) for PD-L1, programmed death receptor 1 (PD-1), lymphocyte activating gene 3 (LAG3), and cluster of differentiation 8 (CD8) antibodies. Statistical analysis was performed with Kaplan-Meier plots and log-rank test. Estimated hazard ratios of dichotomized analysis were calculated, together with 95% confidence intervals and p-values of Wald tests. Results PD-L1 expression was ≥50% in 6 (20%) patients, whereas 19 (63%) had ≥1% expression and 5 (17%) tumor samples were PD-L1-negative. While sex and age had no impact on DFS or OS, <50% PD-L1 expression on tumor cells (TC) was associated with a significantly longer OS (log rank test p=0.037; HR 0.275; 95% CI 0.073-1.03). There was no influence on DFS (log rank test p=0.34; HR 0.599; 95% CI 0.208-1.728). However, <10% PD-L1 expression on tumor infiltrating lymphocytes (TILs) was correlated with a worse DFS (log rank test p=0.0057; HR 4.06; 95% CI 1.389-11.868). LAG3 expression or the number of TILs did not play any prognostic role in our population. Conclusion The PD-L1 expression rate on Caucasians was comparable to that in Asian patients. Although these results have to be interpreted with caution due to the limited number of Caucasian patients available, our data suggest that ≥50% PD-L1 expression on TC is associated with a poor outcome, while ≥10% PD-L1 expression on TILs is correlated with improved DFS. A prospective biomarker analysis of a predefined Caucasian NPC subpopulation would be desirable in future trials." @default.
• W2991353018 created "2019-12-05" @default.
• W2991353018 creator A5002216760 @default.
• W2991353018 creator A5004872477 @default.
• W2991353018 creator A5008966909 @default.
• W2991353018 creator A5011284365 @default.
• W2991353018 creator A5027637525 @default.
• W2991353018 creator A5031817523 @default.
• W2991353018 creator A5039578906 @default.
• W2991353018 date "2019-11-29" @default.
• W2991353018 modified "2023-10-16" @default.
• W2991353018 title "PD-L1 Expression on Tumor Cells Is Associated With a Poor Outcome in a Cohort of Caucasian Nasopharyngeal Carcinoma Patients" @default.
• W2991353018 cites W1495252446 @default.
• W2991353018 cites W151062354 @default.
• W2991353018 cites W1549952528 @default.
• W2991353018 cites W2020720650 @default.
• W2991353018 cites W2031391029 @default.
• W2991353018 cites W2065738562 @default.
• W2991353018 cites W2094230188 @default.
• W2991353018 cites W2104350866 @default.
• W2991353018 cites W2111247797 @default.
• W2991353018 cites W2156682495 @default.
• W2991353018 cites W2185818578 @default.
• W2991353018 cites W2293531514 @default.
• W2991353018 cites W2324258684 @default.
• W2991353018 cites W2405403881 @default.
• W2991353018 cites W2475368493 @default.
• W2991353018 cites W2567510695 @default.
• W2991353018 cites W2588574345 @default.
• W2991353018 cites W2594001971 @default.
• W2991353018 cites W2605920833 @default.
• W2991353018 cites W2607567876 @default.
• W2991353018 cites W2620692834 @default.
• W2991353018 cites W2765696340 @default.
• W2991353018 cites W2768788519 @default.
• W2991353018 cites W2794739281 @default.
• W2991353018 cites W2803936145 @default.
• W2991353018 cites W2804791676 @default.
• W2991353018 cites W2898202669 @default.
• W2991353018 cites W2903493423 @default.
• W2991353018 cites W2947165726 @default.
• W2991353018 cites W2947279694 @default.
• W2991353018 cites W4210983491 @default.
• W2991353018 cites W4211070369 @default.
• W2991353018 doi "https://doi.org/10.3389/fonc.2019.01334" @default.
• W2991353018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6895019" @default.
• W2991353018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31850219" @default.
• W2991353018 hasPublicationYear "2019" @default.
• W2991353018 type Work @default.
• W2991353018 sameAs 2991353018 @default.
• W2991353018 citedByCount "12" @default.
• W2991353018 countsByYear W29913530182020 @default.
• W2991353018 countsByYear W29913530182021 @default.
• W2991353018 countsByYear W29913530182022 @default.
• W2991353018 countsByYear W29913530182023 @default.
• W2991353018 crossrefType "journal-article" @default.
• W2991353018 hasAuthorship W2991353018A5002216760 @default.
• W2991353018 hasAuthorship W2991353018A5004872477 @default.
• W2991353018 hasAuthorship W2991353018A5008966909 @default.
• W2991353018 hasAuthorship W2991353018A5011284365 @default.
• W2991353018 hasAuthorship W2991353018A5027637525 @default.
• W2991353018 hasAuthorship W2991353018A5031817523 @default.
• W2991353018 hasAuthorship W2991353018A5039578906 @default.
• W2991353018 hasBestOaLocation W29913530181 @default.
• W2991353018 hasConcept C10515644 @default.
• W2991353018 hasConcept C121608353 @default.
• W2991353018 hasConcept C126322002 @default.
• W2991353018 hasConcept C143998085 @default.
• W2991353018 hasConcept C167672396 @default.
• W2991353018 hasConcept C203014093 @default.
• W2991353018 hasConcept C207103383 @default.
• W2991353018 hasConcept C2777701055 @default.
• W2991353018 hasConcept C2778997737 @default.
• W2991353018 hasConcept C2781053074 @default.
• W2991353018 hasConcept C44249647 @default.
• W2991353018 hasConcept C509974204 @default.
• W2991353018 hasConcept C66339696 @default.
• W2991353018 hasConcept C71924100 @default.
• W2991353018 hasConcept C72563966 @default.
• W2991353018 hasConcept C8891405 @default.
• W2991353018 hasConceptScore W2991353018C10515644 @default.
• W2991353018 hasConceptScore W2991353018C121608353 @default.
• W2991353018 hasConceptScore W2991353018C126322002 @default.
• W2991353018 hasConceptScore W2991353018C143998085 @default.
• W2991353018 hasConceptScore W2991353018C167672396 @default.
• W2991353018 hasConceptScore W2991353018C203014093 @default.
• W2991353018 hasConceptScore W2991353018C207103383 @default.
• W2991353018 hasConceptScore W2991353018C2777701055 @default.
• W2991353018 hasConceptScore W2991353018C2778997737 @default.
• W2991353018 hasConceptScore W2991353018C2781053074 @default.
• W2991353018 hasConceptScore W2991353018C44249647 @default.
• W2991353018 hasConceptScore W2991353018C509974204 @default.
• W2991353018 hasConceptScore W2991353018C66339696 @default.
• W2991353018 hasConceptScore W2991353018C71924100 @default.
• W2991353018 hasConceptScore W2991353018C72563966 @default.
• W2991353018 hasConceptScore W2991353018C8891405 @default.
• W2991353018 hasLocation W29913530181 @default.
• W2991353018 hasLocation W29913530182 @default.
• W2991353018 hasLocation W29913530183 @default.
• W2991353018 hasLocation W29913530184 @default.

• next