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- W2991356112 abstract "Patients with severe uncontrolled asthma despite best inhalation therapy can receive biologics. In addition to anti-IgE therapy that has improved outcomes in allergic asthma, anti- IL-5 biologic have recently emerged as promising treatments for T2 asthma. Is there any baseline feature that can predict efficacy of therapy? We retrospectively analyzed 20 asmathic patients with good response to Omalizumab (group O) compared to 20 similar patients with unsatisfatory response to omalizumab after 1 yr that were witched to Mepolizumab (group M). All patients were adult, atopic with severe asthma. All patients had positive results for perennial inhalant allergen sensitivity, IgE≥30 KU/L and eosinophil levels ≥ 300/mcL. Regardless of baseline levels of IgE, eosinophil count and baseline exacerbations rate (ER: 5.3±1.75 group O and 5.3±1.53 in group M), some patients had a good response to Omalizumab in the first yr (group O ER 1.3±0.8 p Age may be a predictor of efficacy of monoclonal antibodies in adult allergic asthma. it could help clinicians in the therapeutic decision." @default.
- W2991356112 created "2019-12-05" @default.
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- W2991356112 date "2019-09-28" @default.
- W2991356112 modified "2023-09-27" @default.
- W2991356112 title "Age is a predictor of efficacy of monoclonal antibodies in allergic severe asthma" @default.
- W2991356112 doi "https://doi.org/10.1183/13993003.congress-2019.pa4386" @default.
- W2991356112 hasPublicationYear "2019" @default.
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