Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991358163> ?p ?o ?g. }
- W2991358163 endingPage "110656" @default.
- W2991358163 startingPage "110656" @default.
- W2991358163 abstract "Glucocorticoid actions are mediated by the glucocorticoid receptor (GCR) whose dysfunction leads to glucocorticoid tissue resistance. Our objective was to evaluate GCR-α and GCR-β expression and key steps in the GCR signalling cascade in critical illness. Expression of GCR and major GCR-target genes, cortisol, adrenocorticotropin (ACTH) and cytokines was measured in 42 patients on ICU admission and on days 4, 8, and 13. Twenty-five age- and sex-matched subjects were used as controls. Acutely, mRNA expression of GCR-α was 10-fold and of GCR-β 3-fold the expression of controls, while during the sub-acute phase expression of both isoforms was lower compared to controls. Expression of FKBP5 and GILZ decreased significantly. Cortisol levels remained elevated and ACTH increased during the 13-day period. GCR expression and hypothalamic-pituitary-adrenal axis function undergo a biphasic response during critical illness. The dissociation between low GCR expression and high cortisol implies an abnormal stress response." @default.
- W2991358163 created "2019-12-05" @default.
- W2991358163 creator A5014250584 @default.
- W2991358163 creator A5020990786 @default.
- W2991358163 creator A5024540124 @default.
- W2991358163 creator A5028654415 @default.
- W2991358163 creator A5030984266 @default.
- W2991358163 creator A5034111375 @default.
- W2991358163 creator A5051176601 @default.
- W2991358163 creator A5060168513 @default.
- W2991358163 creator A5063528932 @default.
- W2991358163 creator A5072009497 @default.
- W2991358163 creator A5073129873 @default.
- W2991358163 creator A5090746365 @default.
- W2991358163 date "2020-02-01" @default.
- W2991358163 modified "2023-09-26" @default.
- W2991358163 title "Longitudinal evaluation of glucocorticoid receptor alpha/beta expression and signalling, adrenocortical function and cytokines in critically ill steroid-free patients" @default.
- W2991358163 cites W1606823841 @default.
- W2991358163 cites W1966907779 @default.
- W2991358163 cites W1972316456 @default.
- W2991358163 cites W1980224211 @default.
- W2991358163 cites W1994560731 @default.
- W2991358163 cites W1998086294 @default.
- W2991358163 cites W2007169317 @default.
- W2991358163 cites W2017892333 @default.
- W2991358163 cites W2023342988 @default.
- W2991358163 cites W2026687111 @default.
- W2991358163 cites W2027689592 @default.
- W2991358163 cites W2029813903 @default.
- W2991358163 cites W2031670669 @default.
- W2991358163 cites W2034836489 @default.
- W2991358163 cites W2036845348 @default.
- W2991358163 cites W2044125495 @default.
- W2991358163 cites W2051894528 @default.
- W2991358163 cites W2061084580 @default.
- W2991358163 cites W2063861465 @default.
- W2991358163 cites W2069200792 @default.
- W2991358163 cites W2072425087 @default.
- W2991358163 cites W2074607560 @default.
- W2991358163 cites W2083104211 @default.
- W2991358163 cites W2084883365 @default.
- W2991358163 cites W2087836842 @default.
- W2991358163 cites W2093711197 @default.
- W2991358163 cites W2096846771 @default.
- W2991358163 cites W2098031897 @default.
- W2991358163 cites W2099803817 @default.
- W2991358163 cites W2107277218 @default.
- W2991358163 cites W2113535256 @default.
- W2991358163 cites W2118442033 @default.
- W2991358163 cites W2134399858 @default.
- W2991358163 cites W2140278455 @default.
- W2991358163 cites W2142927411 @default.
- W2991358163 cites W2145161328 @default.
- W2991358163 cites W2146562666 @default.
- W2991358163 cites W2152621598 @default.
- W2991358163 cites W2154233793 @default.
- W2991358163 cites W2159733957 @default.
- W2991358163 cites W2167446140 @default.
- W2991358163 cites W2264198294 @default.
- W2991358163 cites W2280404143 @default.
- W2991358163 cites W2550507245 @default.
- W2991358163 cites W2590131942 @default.
- W2991358163 cites W2784412824 @default.
- W2991358163 cites W2794125559 @default.
- W2991358163 cites W2803157752 @default.
- W2991358163 cites W2913949692 @default.
- W2991358163 doi "https://doi.org/10.1016/j.mce.2019.110656" @default.
- W2991358163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31756425" @default.
- W2991358163 hasPublicationYear "2020" @default.
- W2991358163 type Work @default.
- W2991358163 sameAs 2991358163 @default.
- W2991358163 citedByCount "14" @default.
- W2991358163 countsByYear W29913581632020 @default.
- W2991358163 countsByYear W29913581632021 @default.
- W2991358163 countsByYear W29913581632022 @default.
- W2991358163 countsByYear W29913581632023 @default.
- W2991358163 crossrefType "journal-article" @default.
- W2991358163 hasAuthorship W2991358163A5014250584 @default.
- W2991358163 hasAuthorship W2991358163A5020990786 @default.
- W2991358163 hasAuthorship W2991358163A5024540124 @default.
- W2991358163 hasAuthorship W2991358163A5028654415 @default.
- W2991358163 hasAuthorship W2991358163A5030984266 @default.
- W2991358163 hasAuthorship W2991358163A5034111375 @default.
- W2991358163 hasAuthorship W2991358163A5051176601 @default.
- W2991358163 hasAuthorship W2991358163A5060168513 @default.
- W2991358163 hasAuthorship W2991358163A5063528932 @default.
- W2991358163 hasAuthorship W2991358163A5072009497 @default.
- W2991358163 hasAuthorship W2991358163A5073129873 @default.
- W2991358163 hasAuthorship W2991358163A5090746365 @default.
- W2991358163 hasConcept C104317684 @default.
- W2991358163 hasConcept C126322002 @default.
- W2991358163 hasConcept C134018914 @default.
- W2991358163 hasConcept C150194340 @default.
- W2991358163 hasConcept C170493617 @default.
- W2991358163 hasConcept C2780841215 @default.
- W2991358163 hasConcept C55493867 @default.
- W2991358163 hasConcept C59493245 @default.
- W2991358163 hasConcept C71924100 @default.