FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991398123> ?p ?o ?g. }

• W2991398123 endingPage "1681" @default.
• W2991398123 startingPage "1665" @default.
• W2991398123 abstract "The first reporter systems were developed in the early 1980s and were based on measuring the activity of an enzyme—as a surrogate measure of promoter-driven transcriptional activity—which is now known as a reporter gene system. The initial objective and application of reporter techniques was to analyze the activity of a specific promoter (namely, the expression of a gene that is under the regulation of the specific promoter that is linked to the reporter gene). This system allows visualization of specific promoter activity with great sensitivity. In general, there are 2 classes of reporter systems: constitutively expressed (always-on) reporter constructs used for cell tracking, and inducible reporter systems sensitive to endogenous signaling molecules and transcription factors that characterize specific tissues, tumors, or signaling pathways. This review traces the development of different reporter systems, using <i>fluorescent</i> and <i>bioluminescent</i> proteins as well as <i>radionuclide-based</i> reporter systems. The development and application of <i>radionuclide-based</i> reporter systems is the focus of this review. The question at the end of the review is whether the “promise” of reporter gene imaging has been realized. What is required for moving forward with <i>radionuclide-based</i> reporter systems, and what is required for successful translation to clinical applications?" @default.
• W2991398123 created "2019-12-05" @default.
• W2991398123 creator A5006825449 @default.
• W2991398123 creator A5012407611 @default.
• W2991398123 date "2019-12-01" @default.
• W2991398123 modified "2023-09-29" @default.
• W2991398123 title "Molecular Imaging with Reporter Genes: Has Its Promise Been Delivered?" @default.
• W2991398123 cites W148516797 @default.
• W2991398123 cites W1491952721 @default.
• W2991398123 cites W1492726842 @default.
• W2991398123 cites W1502642136 @default.
• W2991398123 cites W1539503448 @default.
• W2991398123 cites W1591311438 @default.
• W2991398123 cites W1599809900 @default.
• W2991398123 cites W1840175275 @default.
• W2991398123 cites W1869847876 @default.
• W2991398123 cites W1932389800 @default.
• W2991398123 cites W1968603674 @default.
• W2991398123 cites W1968954227 @default.
• W2991398123 cites W1972002559 @default.
• W2991398123 cites W1973804925 @default.
• W2991398123 cites W1974756832 @default.
• W2991398123 cites W1975401072 @default.
• W2991398123 cites W1977382479 @default.
• W2991398123 cites W1978740884 @default.
• W2991398123 cites W1978862919 @default.
• W2991398123 cites W1980154709 @default.
• W2991398123 cites W1980260496 @default.
• W2991398123 cites W1981394935 @default.
• W2991398123 cites W1982233032 @default.
• W2991398123 cites W1983053645 @default.
• W2991398123 cites W1983401915 @default.
• W2991398123 cites W1986513627 @default.
• W2991398123 cites W1987746867 @default.
• W2991398123 cites W1988266325 @default.
• W2991398123 cites W1988513056 @default.
• W2991398123 cites W1990538912 @default.
• W2991398123 cites W1991259883 @default.
• W2991398123 cites W1991919920 @default.
• W2991398123 cites W1992556312 @default.
• W2991398123 cites W1993920492 @default.
• W2991398123 cites W1994216715 @default.
• W2991398123 cites W1995095247 @default.
• W2991398123 cites W1997112554 @default.
• W2991398123 cites W1997818839 @default.
• W2991398123 cites W1998280393 @default.
• W2991398123 cites W2001256439 @default.
• W2991398123 cites W2001914901 @default.
• W2991398123 cites W2004577313 @default.
• W2991398123 cites W2004673553 @default.
• W2991398123 cites W2005201892 @default.
• W2991398123 cites W2005221031 @default.
• W2991398123 cites W2007431577 @default.
• W2991398123 cites W2009345208 @default.
• W2991398123 cites W2010356985 @default.
• W2991398123 cites W2012705446 @default.
• W2991398123 cites W2013472804 @default.
• W2991398123 cites W2017441550 @default.
• W2991398123 cites W2018912704 @default.
• W2991398123 cites W2019108544 @default.
• W2991398123 cites W2020697903 @default.
• W2991398123 cites W2025793830 @default.
• W2991398123 cites W2028813624 @default.
• W2991398123 cites W2030973598 @default.
• W2991398123 cites W2034070883 @default.
• W2991398123 cites W2034240238 @default.
• W2991398123 cites W2035010898 @default.
• W2991398123 cites W2038446250 @default.
• W2991398123 cites W2038756774 @default.
• W2991398123 cites W2039551908 @default.
• W2991398123 cites W2039618053 @default.
• W2991398123 cites W2040601568 @default.
• W2991398123 cites W2040843329 @default.
• W2991398123 cites W2045794140 @default.
• W2991398123 cites W2048669757 @default.
• W2991398123 cites W2049321630 @default.
• W2991398123 cites W2051162118 @default.
• W2991398123 cites W2052512546 @default.
• W2991398123 cites W2054123262 @default.
• W2991398123 cites W2056288782 @default.
• W2991398123 cites W2056809260 @default.
• W2991398123 cites W2057125329 @default.
• W2991398123 cites W2057315336 @default.
• W2991398123 cites W2057572740 @default.
• W2991398123 cites W2060566942 @default.
• W2991398123 cites W2061816768 @default.
• W2991398123 cites W2063616884 @default.
• W2991398123 cites W2065003195 @default.
• W2991398123 cites W2065384679 @default.
• W2991398123 cites W2068778527 @default.
• W2991398123 cites W2068783587 @default.
• W2991398123 cites W2075078812 @default.
• W2991398123 cites W2075534480 @default.
• W2991398123 cites W2077835601 @default.
• W2991398123 cites W2079921929 @default.
• W2991398123 cites W2081262189 @default.
• W2991398123 cites W2081315680 @default.
• W2991398123 cites W2082311924 @default.

• next