Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991416247> ?p ?o ?g. }
- W2991416247 abstract "Abstract The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell population of multipotential stem/progenitor cells commonly referred to as mesenchymal stem cells, multipotential stromal cells, mesenchymal stromal cells, and mesenchymal progenitor cells. The MSCs can differentiate to important lineages under defined conditions in vitro and in limited situations after implantation in vivo. MSCs were isolated and described about 30 years ago and now there are over 55,000 publications on MSCs readily available. Here, we have focused on human MSCs whenever possible. The MSCs have broad anti-inflammatory and immune-modulatory properties. At present, these provide the greatest focus of human MSCs in clinical testing; however, the properties of cultured MSCs in vitro suggest they can have broader applications. The medical utility of MSCs continues to be investigated in over 950 clinical trials. There has been much progress in understanding MSCs over the years, and there is a strong foundation for future scientific research and clinical applications, but also some important questions remain to be answered. Developing further methods to understand and unlock MSC potential through intracellular and intercellular signaling, biomedical engineering, delivery methods and patient selection should all provide substantial advancements in the coming years and greater clinical opportunities. The expansive and growing field of MSC research is teaching us basic human cell biology as well as how to use this type of cell for cellular therapy in a variety of clinical settings, and while much promise is evident, careful new work is still needed." @default.
- W2991416247 created "2019-12-05" @default.
- W2991416247 creator A5028050718 @default.
- W2991416247 creator A5039146199 @default.
- W2991416247 creator A5065558897 @default.
- W2991416247 creator A5085597391 @default.
- W2991416247 creator A5085774808 @default.
- W2991416247 creator A5086513199 @default.
- W2991416247 date "2019-12-02" @default.
- W2991416247 modified "2023-10-12" @default.
- W2991416247 title "Mesenchymal stem cell perspective: cell biology to clinical progress" @default.
- W2991416247 cites W1502442150 @default.
- W2991416247 cites W153481472 @default.
- W2991416247 cites W1548494467 @default.
- W2991416247 cites W1706247353 @default.
- W2991416247 cites W1798466753 @default.
- W2991416247 cites W1830142691 @default.
- W2991416247 cites W1892883644 @default.
- W2991416247 cites W1968628080 @default.
- W2991416247 cites W1972617018 @default.
- W2991416247 cites W1973089587 @default.
- W2991416247 cites W1979782761 @default.
- W2991416247 cites W1979828992 @default.
- W2991416247 cites W1989019426 @default.
- W2991416247 cites W1994553956 @default.
- W2991416247 cites W1997432717 @default.
- W2991416247 cites W2001365534 @default.
- W2991416247 cites W2001634461 @default.
- W2991416247 cites W2013107151 @default.
- W2991416247 cites W2014269161 @default.
- W2991416247 cites W2019495971 @default.
- W2991416247 cites W2021916724 @default.
- W2991416247 cites W2025294489 @default.
- W2991416247 cites W2025371271 @default.
- W2991416247 cites W2025522134 @default.
- W2991416247 cites W2028702444 @default.
- W2991416247 cites W2030637965 @default.
- W2991416247 cites W2030920153 @default.
- W2991416247 cites W2035127869 @default.
- W2991416247 cites W2039665103 @default.
- W2991416247 cites W2039751388 @default.
- W2991416247 cites W2042423362 @default.
- W2991416247 cites W2043759616 @default.
- W2991416247 cites W2045271926 @default.
- W2991416247 cites W2049192852 @default.
- W2991416247 cites W2051297632 @default.
- W2991416247 cites W2058473775 @default.
- W2991416247 cites W2062104876 @default.
- W2991416247 cites W2066682291 @default.
- W2991416247 cites W2068135722 @default.
- W2991416247 cites W2069399162 @default.
- W2991416247 cites W2069641472 @default.
- W2991416247 cites W2070079241 @default.
- W2991416247 cites W2071536607 @default.
- W2991416247 cites W2073767475 @default.
- W2991416247 cites W2074121232 @default.
- W2991416247 cites W2075847434 @default.
- W2991416247 cites W2076491580 @default.
- W2991416247 cites W2080099183 @default.
- W2991416247 cites W2086773479 @default.
- W2991416247 cites W2089878334 @default.
- W2991416247 cites W2090193322 @default.
- W2991416247 cites W2092839502 @default.
- W2991416247 cites W2094024512 @default.
- W2991416247 cites W2095666785 @default.
- W2991416247 cites W2100764718 @default.
- W2991416247 cites W2101986300 @default.
- W2991416247 cites W2102041100 @default.
- W2991416247 cites W2104113751 @default.
- W2991416247 cites W2105231460 @default.
- W2991416247 cites W2105998918 @default.
- W2991416247 cites W2108819293 @default.
- W2991416247 cites W2110148884 @default.
- W2991416247 cites W2110980549 @default.
- W2991416247 cites W2111727066 @default.
- W2991416247 cites W2112777549 @default.
- W2991416247 cites W2113547540 @default.
- W2991416247 cites W2113619226 @default.
- W2991416247 cites W2116864112 @default.
- W2991416247 cites W2117479856 @default.
- W2991416247 cites W2124925707 @default.
- W2991416247 cites W2124948262 @default.
- W2991416247 cites W2131092033 @default.
- W2991416247 cites W2133375451 @default.
- W2991416247 cites W2134208433 @default.
- W2991416247 cites W2138811791 @default.
- W2991416247 cites W2141738357 @default.
- W2991416247 cites W2141844425 @default.
- W2991416247 cites W2143742274 @default.
- W2991416247 cites W2146337514 @default.
- W2991416247 cites W2146710021 @default.
- W2991416247 cites W2147691664 @default.
- W2991416247 cites W2147822820 @default.
- W2991416247 cites W2153400990 @default.
- W2991416247 cites W2155403628 @default.
- W2991416247 cites W2159358845 @default.
- W2991416247 cites W2159999899 @default.
- W2991416247 cites W2161708262 @default.
- W2991416247 cites W2162412444 @default.
- W2991416247 cites W2162907904 @default.