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• W2991417598 abstract "Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism, HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts." @default.
• W2991417598 created "2019-12-05" @default.
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• W2991417598 date "2019-11-25" @default.
• W2991417598 modified "2023-10-17" @default.
• W2991417598 title "The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia" @default.
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• W2991417598 doi "https://doi.org/10.1038/s41467-019-13259-2" @default.
• W2991417598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6877618" @default.
• W2991417598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31767858" @default.

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