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• W2991444663 startingPage "63" @default.
• W2991444663 abstract "Historically, CD34+ cells were harvested from donors by repeated aspiration of the bone marrow. Over the last 20 years, peripheral blood has become the preferred graft source for allogeneic hematopoietic cell transplantation. There are advantages and disadvantages of utilizing peripheral blood-mobilized hematopoietic progenitor cells compared to bone marrow. According to National Marrow Donor Program (NMDP) guidelines, no more than 20 mL of marrow/kg is collected in one bone marrow harvest which may limit the number of CD34+ hematopoietic progenitor cells that can be collected. Conversely, donors can undergo multiple days of apheresis, and any restrictions on volumes are for logistical concerns rather than safety. High number of hematopoietic progenitor cells are needed for successful allogeneic hematopoietic cell transplant than it is possible to collect under normal conditions; thus, donors must undergo hematopoietic progenitor cells mobilization prior to collection. Hematopoietic progenitor cells mobilization in healthy donors is performed utilizing cytokines exclusively. Even among healthy donors, approximately 2–6% do not collect a minimum of 2 × 106 CD34+ cells/kg body weight (“minimal goal”) after two apheresis procedures and constitute “poor mobilizers.” Apheresis can be planned to coincide with conditioning regimen in the case of related donor allogeneic hematopoietic cell transplant, and as such, apheresis product can be transfused without cryopreserving (“fresh”). Other cytokines (GM-CSF/PEG-filgrastim) and chemokine antagonists (plerixafor) have not currently replaced G-CSF. New mobilizing agents and combinations of agents are making their way through preclinical and early clinical trials and may eventually provide more rapid, robust, and safe alternatives to mobilizing normal donors for allogeneic hematopoietic cell transplantation." @default.
• W2991444663 created "2019-12-05" @default.
• W2991444663 creator A5021003906 @default.
• W2991444663 creator A5065066309 @default.
• W2991444663 creator A5075593082 @default.
• W2991444663 date "2019-11-28" @default.
• W2991444663 modified "2023-09-25" @default.
• W2991444663 title "Mobilization Strategies: HPC(A) Collections for Allogeneic Hematopoietic Cell Transplants" @default.
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