Matches in SemOpenAlex for { <https://semopenalex.org/work/W2991451088> ?p ?o ?g. }
- W2991451088 endingPage "1365" @default.
- W2991451088 startingPage "1359" @default.
- W2991451088 abstract "Alzheimer's disease is the leading cause of dementia, effecting majority of aged people worldwide. The multifaceted effectors of Alzheimer's disease primarily include Tau, amyloid-β along with hyper activation of kinases, oxidative stress and mutations etc., makes it challenging to design therapeutics. Tau is a microtubule-associating protein, which is subjected to cellular stress resulting in the formation of neurofibrillary tangles, leading to loss of affinity for microtubules. This causes loss of microtubule stability and in turn alters axonal integrity. In the present work, emphasis towards understanding interaction of nickel with Tau was made. Metals such as iron, zinc, copper and lead etc., are known to modulate Tau conformation and enhance its aggregation. Our results showed the deliverance of Tau aggregation by nickel and its synthetic morpholine conjugate. Nickel prevents aggregation by inducing degradation of Tau as evidenced by SDS-PAGE and TEM. Nickel and the synthetic conjugate being non-toxic to neuro2a cells and prevent Tau aggregation, might direct these complexes to overcome AD." @default.
- W2991451088 created "2019-12-05" @default.
- W2991451088 creator A5021550062 @default.
- W2991451088 creator A5025119113 @default.
- W2991451088 creator A5032489018 @default.
- W2991451088 creator A5034873753 @default.
- W2991451088 date "2020-08-01" @default.
- W2991451088 modified "2023-10-03" @default.
- W2991451088 title "Transition metal nickel prevents Tau aggregation in Alzheimer's disease" @default.
- W2991451088 cites W110508544 @default.
- W2991451088 cites W1488741256 @default.
- W2991451088 cites W1533318596 @default.
- W2991451088 cites W1582795354 @default.
- W2991451088 cites W1613574700 @default.
- W2991451088 cites W1842644041 @default.
- W2991451088 cites W1971165215 @default.
- W2991451088 cites W1975040221 @default.
- W2991451088 cites W1980333932 @default.
- W2991451088 cites W2008132152 @default.
- W2991451088 cites W2014210332 @default.
- W2991451088 cites W2015890929 @default.
- W2991451088 cites W2021348357 @default.
- W2991451088 cites W2027220567 @default.
- W2991451088 cites W2029010422 @default.
- W2991451088 cites W2033807567 @default.
- W2991451088 cites W2040920876 @default.
- W2991451088 cites W2057436204 @default.
- W2991451088 cites W2066419835 @default.
- W2991451088 cites W2074059686 @default.
- W2991451088 cites W2104945061 @default.
- W2991451088 cites W2111200377 @default.
- W2991451088 cites W2133324295 @default.
- W2991451088 cites W2141133962 @default.
- W2991451088 cites W2149996174 @default.
- W2991451088 cites W2160636151 @default.
- W2991451088 cites W2310723464 @default.
- W2991451088 cites W2502163229 @default.
- W2991451088 cites W2555588985 @default.
- W2991451088 cites W2593745455 @default.
- W2991451088 cites W2598291967 @default.
- W2991451088 cites W2605036205 @default.
- W2991451088 cites W2616724130 @default.
- W2991451088 cites W2754334814 @default.
- W2991451088 cites W2762504850 @default.
- W2991451088 cites W2765592275 @default.
- W2991451088 cites W2767332403 @default.
- W2991451088 cites W2782509615 @default.
- W2991451088 cites W2790798430 @default.
- W2991451088 cites W2796392176 @default.
- W2991451088 cites W2801323635 @default.
- W2991451088 cites W2869534525 @default.
- W2991451088 cites W2909437563 @default.
- W2991451088 cites W2913487845 @default.
- W2991451088 cites W2950505031 @default.
- W2991451088 cites W2964552141 @default.
- W2991451088 cites W2978428954 @default.
- W2991451088 cites W4211139529 @default.
- W2991451088 cites W4362221370 @default.
- W2991451088 cites W47608607 @default.
- W2991451088 doi "https://doi.org/10.1016/j.ijbiomac.2019.11.176" @default.
- W2991451088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31770557" @default.
- W2991451088 hasPublicationYear "2020" @default.
- W2991451088 type Work @default.
- W2991451088 sameAs 2991451088 @default.
- W2991451088 citedByCount "12" @default.
- W2991451088 countsByYear W29914510882020 @default.
- W2991451088 countsByYear W29914510882021 @default.
- W2991451088 countsByYear W29914510882022 @default.
- W2991451088 countsByYear W29914510882023 @default.
- W2991451088 crossrefType "journal-article" @default.
- W2991451088 hasAuthorship W2991451088A5021550062 @default.
- W2991451088 hasAuthorship W2991451088A5025119113 @default.
- W2991451088 hasAuthorship W2991451088A5032489018 @default.
- W2991451088 hasAuthorship W2991451088A5034873753 @default.
- W2991451088 hasConcept C12554922 @default.
- W2991451088 hasConcept C134306372 @default.
- W2991451088 hasConcept C136238340 @default.
- W2991451088 hasConcept C142724271 @default.
- W2991451088 hasConcept C178790620 @default.
- W2991451088 hasConcept C185592680 @default.
- W2991451088 hasConcept C197336794 @default.
- W2991451088 hasConcept C20418707 @default.
- W2991451088 hasConcept C2776151105 @default.
- W2991451088 hasConcept C2778670691 @default.
- W2991451088 hasConcept C2779134260 @default.
- W2991451088 hasConcept C33923547 @default.
- W2991451088 hasConcept C502032728 @default.
- W2991451088 hasConcept C504270822 @default.
- W2991451088 hasConcept C55493867 @default.
- W2991451088 hasConcept C71924100 @default.
- W2991451088 hasConcept C86803240 @default.
- W2991451088 hasConcept C95444343 @default.
- W2991451088 hasConceptScore W2991451088C12554922 @default.
- W2991451088 hasConceptScore W2991451088C134306372 @default.
- W2991451088 hasConceptScore W2991451088C136238340 @default.
- W2991451088 hasConceptScore W2991451088C142724271 @default.
- W2991451088 hasConceptScore W2991451088C178790620 @default.
- W2991451088 hasConceptScore W2991451088C185592680 @default.