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- W2991462218 abstract "Site-directed RNA editing (SDRE) is invaluable to basic research and clinical applications and has emerged as a new frontier in genome editing. The past few years have witnessed a surge of interest in SDRE, with SDRE tools emerging at a breathtaking pace. However, off-target effects of SDRE remain a tough problem, which constitutes a major hurdle to their clinical applications. Here we discuss the diverse strategies for combating off-target editing, drawing lessons from the published studies as well as our ongoing research. Overall, SDRE is still at its infancy, with significant challenges and exciting opportunities ahead." @default.
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- W2991462218 date "2019-11-01" @default.
- W2991462218 modified "2023-09-26" @default.
- W2991462218 title "Site-directed RNA editing (SDRE): Off-target effects and their countermeasures" @default.
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- W2991462218 doi "https://doi.org/10.1016/j.jgg.2019.11.005" @default.
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