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• W2991465818 endingPage "107125" @default.
• W2991465818 startingPage "107125" @default.
• W2991465818 abstract "Brain-derived neurotrophic factor (BDNF) is an essential product of protein synthesis with a prominent impact on brain signaling and synaptic plasticity. Exogenous application of this neurotrophin is able to induce long-term potentiation (LTP) in several brain structures such as the hippocampus along with increases in gene transcription and translation of proteins involved in functional and structural plasticity. In this regard, our previous studies have demonstrated that acute intrahippocampal administration of BDNF induces long-lasting enhancement of synaptic transmission at the mossy fibers projection (MF) accompanied by a structural reorganization at the CA3 hippocampus area. Thus, considering the non-canonical molecular mechanisms underlying MF-CA3-LTP and the high expression of this neurotrophin in the CA3 area, we wonder whether transcriptional and translational inhibition interferes with the persistence of the MF functional and structural synaptic plasticity elicited by BDNF in adult rats in vivo. Our results show that BDNF is able to induce a lasting potentiation of synaptic efficacy at the MF projection accompanied by a structural reorganization at the CA3 area in an mRNA synthesis and protein translation-independent manner. The present findings support the idea that BDNF is an essential plasticity related product, which is necessary and sufficient to induce and maintain functional and structural synaptic plasticity at the MF-CA3 pathway." @default.
• W2991465818 created "2019-12-05" @default.
• W2991465818 creator A5016578877 @default.
• W2991465818 creator A5028536391 @default.
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• W2991465818 date "2020-01-01" @default.
• W2991465818 modified "2023-10-12" @default.
• W2991465818 title "BDNF induces in vivo long-lasting enhancement of synaptic transmission and structural reorganization at the hippocampal mossy fibers in a transcription and translation-independent manner" @default.
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• W2991465818 doi "https://doi.org/10.1016/j.nlm.2019.107125" @default.
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• W2991465818 hasPublicationYear "2020" @default.
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