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• W2991480431 abstract "Rheumatoid arthritis (RA) is a chronic synovial autoinflammatory disease that destructs the cartilage and bone, leading to disability. The functional regulation of major immunity-related pathways like nuclear factor kappa B (NF-κB), which is involved in the chronic inflammatory reactions underlying the development of RA, remains to be explored. Therefore, this study has adopted statistical and knowledge-based systemic investigations (like gene correlation, semantic similarity, and topological parameters based on graph theory) to study the gene expression status of NF-κB protein family (NKPF) and its regulators in synovial tissues to trace the molecular pathways through which these regulators contribute to RA. A complex protein-protein interaction map (PPIM) of 2,742 genes and 37,032 interactions was constructed from differentially expressed genes (p ≤ 0.05). PPIM was further decomposed into a Regulator Allied Protein Interaction Network (RAPIN) based on the interaction between genes (5 NKPF, 31 seeds, 131 hubs, and 652 bottlenecks). Pathway network analysis has shown the RA-specific disturbances in the functional connectivity between seed genes (RIPK1, ATG7, TLR4, TNFRSF1A, KPNA1, CFLAR, SNW1, FOSB, PARVA, CX3CL1, and TRPC6) and NKPF members (RELA, RELB, NFKB2, and REL). Interestingly, these genes are known for their involvement in inflammation and immune system (signaling by interleukins, cytokine signaling in immune system, NOD-like receptor signaling, MAPK signaling, Toll-like receptor signaling, and TNF signaling) pathways connected to RA. This study, for the first time, reports that SNW1, along with other NK regulatory genes, plays an important role in RA pathogenesis and might act as potential biomarker for RA. Additionally, these genes might play important roles in RA pathogenesis, as well as facilitate the development of effective targeted therapies. Our integrative data analysis and network-based methods could accelerate the identification of novel drug targets for RA from high-throughput genomic data." @default.
• W2991480431 created "2019-12-05" @default.
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• W2991480431 date "2019-11-20" @default.
• W2991480431 modified "2023-10-14" @default.
• W2991480431 title "Dissecting the Role of NF-κb Protein Family and Its Regulators in Rheumatoid Arthritis Using Weighted Gene Co-Expression Network" @default.
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• W2991480431 cites W1976391393 @default.
• W2991480431 cites W1987055888 @default.
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• W2991480431 cites W2062533676 @default.
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• W2991480431 cites W2135602701 @default.
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• W2991480431 cites W2164305413 @default.
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• W2991480431 doi "https://doi.org/10.3389/fgene.2019.01163" @default.
• W2991480431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6879671" @default.
• W2991480431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31824568" @default.
• W2991480431 hasPublicationYear "2019" @default.
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