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• W2991491027 abstract "Future Science Book SeriesHot Topics in Metabolomics: Food and Nutrition Metabolomics of genetically modified cropsThomas Frank & Karl-Heinz EngelThomas FrankThomas Frank studied technology and biotechnology of foods and received his PhD degree at the Technische Universität München (Germany). He is a Senior Researcher under Karl-Heinz Engel´s chair and works on the development and application of different metabolomics techniques to the investigation of quality and safety of various plant-derived genetically modified and non-genetically modified crops. He has published his results in high-impact peer-reviewed journals, book chapters and in the form of invited speeches at several symposia.Search for more papers by this author & Karl-Heinz EngelKarl-Heinz Engel studied food chemistry at the TH Karlsruhe (Germany) and received his PhD at the TU Berlin (Germany). After a research stay at the Western Regional Research Center of the US Department of Agriculture in Albany (CA, USA), he completed his qualification as University Professor in Berlin. Prior to his appointment as Professor at the Technische Universität München, he was Head of the section ‘Novel Foods and Genetic Engineering’ at the Federal Institute for Health Protection of Consumers and Veterinary Medicine (Berlin, Germany). He is also a member of scientific panels of the European Food Safety Authority (EFSA) where he is mainly involved in the safety assessment of flavorings and novel foods. His research centers on analytical aspects related to food safety and authenticity. His area of expertise is reflected by several hundred published journal articles, book chapters, scientific EFSA opinions and invited speeches.Search for more papers by this authorPublished Online:17 Dec 2013https://doi.org/10.4155/ebo.13.323AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInRedditEmail View chapterAbstract: Metabolomics – that is, the unbiased and nontargeted analysis of the metabolome in an organic tissue – has been suggested as a suitable tool for the comprehensive investigation of genetically modified (GM) crop metabolite profiles. This chapter gives a brief overview on selected case studies where metabolomics has been applied to the comparative investigation of various GM crops and their corresponding non-GM counterparts. In addition, the chapter outlines the impact of genetic modification in the light of the naturally occurring metabolic variability. Before GM crops can be placed on the market, they have to be subjected to a comprehensive assessment. Potential advantages and limitations of the application of nontargeted metabolomics-based analytical approaches in this procedure are outlined. References1 Noteborn HPJM , Lommen A , van der Jagt RC et al. Chemical fingerprinting for the evaluation of unintended secondary metabolic changes in transgenic food crops . J. Biotechnol. 77 (1) , 103 – 114 (2000) . Crossref, Medline, CAS, Google Scholar2 Roessner U , Luedemann A , Brust D et al. Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems . Plant Cell 13 (1) , 11 – 29 (2001) . Crossref, Medline, CAS, Google Scholar3 Shintu L , Le Gall G , Colquhoun IJ . Metabolomics and the detection of unintended effects in genetically modified crops. In: Plant-Derived Natural Products. Osbourn AE, Lanzotti V (Eds). Springer Science + Business Media LLC, Dordrecht, The Netherlands (2009) . 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Unintended compositional changes in genetically modified (GM) crops: 20 years of research . J. Agric. Food Chem. doi:10.1021/jf400135r (2013) (Epub ahead of print) . Crossref, Google Scholar25 Chassy BM . Can – omics inform a food safety assessment? . Regul. Toxicol. Pharmacol. 58 , S62 – S70 (2010) . Crossref, Medline, Google Scholar26 Doerrer N , Ladics G , McClain S et al. Evaluating biological variation in non-transgenic crops: executive summary from the ILSI Health and Environmental Sciences Institute workshop, November 16–17, 2009, Paris, France . Regul. Toxicol. Pharmacol. 58 , S2 – S7 (2010) . Crossref, Medline, Google ScholarWebsite101 James C. Global status of commercialized biotech/GM crops: 2012. ISAAA Brief No. 44. ISAAA. Ithaca, NY, USA (2013). www.isaaa.org/resources/publications/briefs/44/executivesummary Google ScholarFiguresReferencesRelatedDetailsCited ByLC–MS untargeted metabolomics assesses the delayed response of glufosinate treatment of transgenic glufosinate resistant (GR) buffalo grasses (Stenotaphrum secundatum L.)20 February 2021 | Metabolomics, Vol. 17, No. 3Recent developments in metabolomics-based research in understanding transgenic grass metabolism15 March 2019 | Metabolomics, Vol. 15, No. 4 Hot Topics in Metabolomics: Food and NutritionMetrics Downloaded 23 times History Published online 17 December 2013 Published in print December 2013 Information© Future Science Ltd© Future Science LtdPDF download" @default.
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