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- W2991495225 endingPage "1381.e12" @default.
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- W2991495225 abstract "The synthesis of new ribosomes begins during transcription of the rRNA and is widely assumed to follow an orderly 5′ to 3′ gradient. To visualize co-transcriptional assembly of ribosomal protein-RNA complexes in real time, we developed a single-molecule platform that simultaneously monitors transcription and protein association with the elongating transcript. Unexpectedly, the early assembly protein uS4 binds newly made pre-16S rRNA only transiently, likely due to non-native folding of the rRNA during transcription. Stable uS4 binding became more probable only in the presence of additional ribosomal proteins that bind upstream and downstream of protein uS4 by allowing productive assembly intermediates to form earlier. We propose that dynamic sampling of elongating RNA by multiple proteins overcomes heterogeneous RNA folding, preventing assembly bottlenecks and initiating assembly within the transcription time window. This may be a common feature of transcription-coupled RNP assembly." @default.
- W2991495225 created "2019-12-05" @default.
- W2991495225 creator A5069816120 @default.
- W2991495225 creator A5078281937 @default.
- W2991495225 date "2019-11-01" @default.
- W2991495225 modified "2023-10-15" @default.
- W2991495225 title "Transcription Increases the Cooperativity of Ribonucleoprotein Assembly" @default.
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- W2991495225 doi "https://doi.org/10.1016/j.cell.2019.11.007" @default.
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